PMID: 8971561Dec 1, 1996Paper

Immunohistochemical localization of Mcl-1 and bcl-2 proteins in thymic epithelial tumours

Histopathology
F F ChenY T Jin

Abstract

Mcl-1 protein is a new member of the bcl-2 protein family. It is believed to be a blocker of apoptosis but might be different from bcl-2 in the control of apoptosis. Using immunostaining of formalin-fixed, paraffin-embedded sections, we investigated the expression of Mcl-1 in 42 thymic epithelial tumours: three medullary thymomas, five mixed thymomas, seven cortical thymomas, eight well-differentiated thymic carcinomas, 14 squamous cell carcinomas, four lymphoepithelioma-like carcinomas and one undifferentiated carcinoma, bcl-2 immunocytochemical localization was also performed for comparison. High-grade thymic carcinomas, especially squamous cell carcinomas, revealed more intense Mcl-1 immunoreactivity as compared to other subtypes (P < 0.001). In cases that co-expressed Mcl-1 and bcl-2, the less differentiated cells had more intense expression of bcl-2, while the more differentiated cells displayed stronger Mcl-1 immunoreactivity. The differential expression of Mcl-1 and bcl-2 in neoplastic cells provides evidence that these proteins may play different roles in the processes of programmed cell death in thymic neoplasms. The finding that thymic carcinomas have stronger immunoreactivity for Mcl-1 indicates that this protein cou...Continue Reading

Citations

Jul 18, 2002·Histopathology·R L AttanoosS D Dojcinov
Dec 31, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Enzo FalloneHaodong Xu
Jun 24, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P EngelN Graem
Sep 12, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·M W DattaD M Dorfman
Oct 13, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Maria BaiPanagiotis Kanavaros
Aug 28, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Annikka WeissferdtCesar A Moran
Nov 13, 2010·Thoracic Surgery Clinics·Mirella Marino, Mauro Piantelli
Nov 7, 2001·The American Journal of Pathology·R ZhouP Starostik
Sep 18, 2002·Pathology, Research and Practice·Sung-Hye ParkJae Y Ro
Oct 8, 2003·The Annals of Thoracic Surgery·Yau-Lin TsengFen-Fen Cheng
Mar 22, 2015·Clinical and Experimental Medicine·Alexandra Papoudou-BaiPanagiotis Kanavaros
Aug 27, 2011·Bulletin de la Société de pathologie exotique·S SerafiniD Massenet
May 29, 2008·Arquivos brasileiros de endocrinologia e metabologia·Tânia A RodriguesDolores López

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.