Immunohistochemical localization of nerve fibres during development of embryonic rat molar using peripherin and protein gene product 9.5 antibodies

Archives of Oral Biology
K Luukko

Abstract

Nerve fibres were localized during the initiation and early morphogenesis of the first molar tooth in rat embryos by immunoperoxidase detection of the intermediate-filament protein peripherin and protein gene product 9.5 (PGP 9.5). Nerve fibres from the trigeminal ganglion were detected in the developing first branchial arch of E12-14 embryos. Nerves were not seen in the vicinity of the developing tooth germ before the buid stage (E15), when they were seen around the condensed dental mesenchyme. During transition from the bud to the cap stage (E15), nerve fibres were detected not only in the area of the future dental follicle but also in the mesenchyme next to dental epithelium on the buccal side of the tooth germ. During later cap and bell stages nerve fibres persisted in the dental follicle, but they were not seen in the epithelial dental organ or dental papilla mesenchyme. Absence of trigeminal nerve fibres from the presumptive tooth-bearing area indicates that they are not involved in the initiation of rat tooth development. In addition, the localization of nerve fibres shows that there are some differences in the innervation of rat teeth compared with human and mouse teeth. These results provide data for further studies on...Continue Reading

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Citations

Oct 23, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K LuukkoI Thesleff
Dec 10, 1999·The Anatomical Record·J P NaftelJ M Bernanke
Jan 8, 2014·Cellular and Molecular Life Sciences : CMLS·Pierfrancesco PagellaThimios A Mitsiadis
Nov 13, 2012·Differentiation; Research in Biological Diversity·Kyaw MoeKeijo Luukko
Jul 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sigbjørn LøesPäivi Kettunen
Oct 12, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Keijo LuukkoPäivi Kettunen
Sep 10, 2014·Frontiers in Physiology·Pierfrancesco PagellaThimios A Mitsiadis
Sep 21, 2016·Stem Cells International·Shayee MiranPierfrancesco Pagella
Oct 24, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K LuukkoI Thesleff
Oct 6, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·K FriedC Hildebrand
Jul 1, 1997·Journal of Dental Research·K LuukkoI Thesleff
Feb 12, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K LuukkoI Thesleff
Jan 25, 2013·Case Reports in Infectious Diseases·K Ibn Majdoub HassaniK Mazaz
Oct 11, 2003·Archives of Oral Biology·Cezara ZmijewskaMaciej Zabel

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