PMID: 490194Aug 1, 1979Paper

Immunohistochemical localization of neurofilament antigen in rat cerebellum

Journal of Neurocytology
A I MatusD H Jones

Abstract

The distribution of neurofilaments in the rat cerebellar cortex was studied by immunoperoxidase histochemistry using an antiserum raised against neurofilaments isolated from brain (anti-NF). In light microscope preparations, this antiserum selectively stained known neurofilament-containing structures. Staining was most intense in myelinated axons of the white matter and in the terminal branches of basket cell axons. No staining was apparent in either neuronal or glial cell bodies or in glial cell processes. These findings were confirmed in electron microscopic preparations of the same material. Neurofilaments stained by the antiserum were abundant in basket cell axons and also occurred in small bundles in mossy fibre terminals. Adjacent microtubules were not stained by the antiserum. There was no evidence of stained cytoplasmic filaments in glial cell processes. Thus it appears that neurofilaments contain unique antigens which do not occur in either microtubules or in glial cytoplasmic filaments. The antiserum did not induce staining of synaptic junctional structures, a result which contradicts previous suggestions that neurofilaments are structural components of synaptic densities.

References

Dec 4, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A I Matus, D H Taff-Jones
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S H YenM L Shelanski
Dec 15, 1977·The Journal of Comparative Neurology·D Dahl, A Bignami
Aug 19, 1977·Brain Research·S H YenM L Shelanski
Dec 25, 1975·Nature·A Matus, S Mughal
Dec 25, 1975·Nature·K G HaglidL Rönnbäck
Oct 9, 1975·Nature·B B Walters, A I Matus
Nov 1, 1974·Journal of Neurocytology·V Chan-PalayS M Billings-Gagliardi
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Jan 1, 1969·Progress in Brain Research·E G Gray
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Citations

Dec 1, 1980·Journal of Neurocytology·B H AndertonP Woodhams
Oct 1, 1989·Brain Research. Developmental Brain Research·M A EdwardsM Yamamoto
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·W van RaamsdonkJ L Groen
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A BignamiD Dahl
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C Ayer-LelievreA Seiger
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A MatusT Hugh-Jones
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R HawkesA Matus
Feb 1, 1985·The Journal of Cell Biology·G HuberA Matus
Nov 1, 1980·The Journal of Cell Biology·A MatusJ Maeder
Nov 1, 1982·Journal of Neuroimmunology·M E GoldsteinL A Sternberger
Dec 1, 1981·Journal of Neuroimmunology·M C FrankoD C Gajdusek
Jan 1, 1982·Journal of Neurochemistry·R K CarlinP Siekevitz
Mar 1, 1986·Journal of Neurochemistry·M VitadelloS Schiaffino
Feb 1, 1984·Journal of Neurochemistry·R HawkesA Matus
Feb 1, 1983·Journal of Neurochemistry·B A BrownC A Marotta
Jan 1, 1987·Cell Motility and the Cytoskeleton·C E HartJ G Wood
Mar 1, 1984·The Journal of Comparative Neurology·A SeigerH Björklund
May 2, 1983·Klinische Wochenschrift·K MrossH Rauschecker
Sep 8, 2001·The Journal of Biological Chemistry·A el-D El-HusseiniD S Bredt
Jun 1, 1981·Journal of Muscle Research and Cell Motility·B H Anderton
Jan 22, 1996·The Journal of Comparative Neurology·B M RiedererR A Marugg
Feb 1, 1981·The Journal of Comparative Neurology·D DahlN H Chi

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