PMID: 15033994Mar 23, 2004Paper

Immunohistochemical localization of peroxisomal enzymes during rat embryonic development

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Roberta NardacciS Stefanini

Abstract

Peroxisomes are cytoplasmic organelles involved in a variety of metabolic pathways. Thus far, the morphological and biochemical features of peroxisomes have been extensively characterized in adult tissues. However, the existence of congenital peroxisomal disorders, primarily affecting tissue differentiation, emphasizes the importance of these organelles in the early stages of organogenesis. We investigated the occurrence and tissue distribution of three peroxisomal enzymes in rat embryos at various developmental stages. By means of a highly sensitive biotinyl-tyramide protocol, catalase, acyl-CoA oxidase, and ketoacyl-CoA thiolase were detected in embryonic tissues where peroxisomes had not thus far been recognized, i.e., adrenal and pancreatic parenchyma, choroid plexus, neuroblasts of cranial and spinal ganglia and myenteric plexus, and chondroblasts of certain skeletal structures. In other tissues, i.e., gut epithelium and neuroblasts of some CNS areas, they were identified earlier than previously. In select CNS areas, ultrastructural catalase cytochemistry allowed identification of actively proliferating organelles at early developmental stages in several cell types. Our data show that in most organs maturation of peroxisom...Continue Reading

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Citations

Mar 4, 2006·Histochemistry and Cell Biology·Jukka KallijärviAnna-Elina Lehesjoki
Feb 23, 2011·Antioxidants & Redox Signaling·Caroline Coisne, Britta Engelhardt
Aug 7, 2013·Fluids and Barriers of the CNS·Ingrid KratzerJean-Francois Ghersi-Egea
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Nov 9, 2004·Toxicon : Official Journal of the International Society on Toxinology·G D'SuzeN Bracho
Jan 17, 2017·Molecular Neurobiology·Lucineia Gainski DanielskiFabrícia Petronilho

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