PMID: 7032198Nov 1, 1981Paper

Immunohistochemical localization of type I, III and IV (basement membrane) collagens in the liver

Acta Pathologica Japonica
H KonomiY Nagai

Abstract

The tissue distribution of type I, III and IV (basement membrane) collagens in normal human and bovine livers was examined by indirect immunofluorescence microscopy, by using type-specific rabbit antibodies to individual types of bovine collagen. Type I and III collagens were found to distribute in the interstitium of portal tracts as thick fiber bundles and in perisinusoidal spaces as thin fibers like reticulin fibers, both in human and bovine livers. No significant distribution differences of type I and III collagens in the livers was observed under the experimental conditions employed, indicating that both collagens are involved in in vivo collagen, fibrillogenesis in the tissue, regardless of the sizes of collagen fibers, as in the skin (Conn. Tiss. Res. 7: 157-163, 1980). Type IV collagen, when examined with bovine liver, was located in hepatic arteries, portal veins and bile ducts of portal tracts, and was also distributed in the perisinusoidal spaces in a linear fasion.

References

Feb 1, 1977·The Journal of Clinical Investigation·J M SeyerA H Kang
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·G KentH Popper
Jan 1, 1982·Archives of Dermatological Research·S TajimaY Nagai
Jul 1, 1981·Acta Pathologica Japonica·H KonomiY Nagai

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Citations

Mar 1, 1989·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·P Y RescanA Guillouzo
Jan 1, 1987·Acta histochemica·M RuzickováM Brozman
Nov 1, 1988·Pathology, Research and Practice·T KarttunenH Autio-Harmainen
Oct 11, 2008·Tissue Engineering. Part C, Methods·Randall McClellandLola M Reid
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Shotaro NishimuraShoji Tabata
Feb 1, 1988·Journal of Neurosurgery·J T RutkaM L Rosenblum
Jan 1, 1989·Connective Tissue Research·R S Aycock, J M Seyer
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MilaniH Stein

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