PMID: 9557964Apr 29, 1998Paper

Immunohistochemical localization of vascular endothelial growth factor in the endocrine glands of the rat

Archives of Histology and Cytology
L Fan, S Iseki

Abstract

Vascular endothelial growth factor (VEGF) is a secreted polypeptide with specific effects on endothelial cell growth and vascular permeability. While previous studies have focused on the expression of VEGF associated with angiogenesis in tumor and embryonal tissues, little is known about the role of VEGF in normal adult tissues. In the present study, a specific antibody was used to study the immunohistochemical localization of VEGF in the entire body of normal adult rats. Intense to moderate immunoreactivities for VEGF were detected in some endocrine cell types, namely, the parafollicular cell of thyroid gland, B cell of endocrine pancreas, N cell of adrenal medulla and a minority of the thyrotrophs of the pituitary gland. A certain exocrine cell type, i.e., the surface mucous cell of stomach, was also immunoreactive for VEGF. At the ultrastructural level, VEGF immunoreactivity was localized exclusively in the secretory granules of all immunopositive endocrine and exocrine cells examined. The present study provided immunohistochemical evidence for the occurrence of VEGF in subsets of endocrine and exocrine cells of normal adult rats, suggesting that these secretory cells regulate local vascular permeability through a paracrine ...Continue Reading

Citations

Jul 13, 2002·Endocrine Pathology·Ricardo V. LloydLucia Stefaneanu
Oct 1, 2003·Gastroenterology·Anne-Marie Marion-AudibertJean-Yves Scoazec
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yunlong YangYihai Cao
Mar 25, 2006·Future Oncology·David O Bates, Steven J Harper
Jul 23, 2014·Nature Reviews. Endocrinology·Yihai Cao
Aug 19, 2008·The Journal of Surgical Research·Gilles PoncetColette Roche
Aug 3, 2006·Surgical Oncology Clinics of North America·Rasa ZarnegarOrlo H Clark
Sep 25, 2015·Respiratory Research·Tamera CorteJoseph A Lasky
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Eugenio Bertelli, Moïse Bendayan
Mar 2, 2016·Therapeutic Advances in Gastroenterology·Alessandro GranitoLuigi Bolondi
Jun 20, 2001·Biological & Pharmaceutical Bulletin·I SakaguchiK Kaneda
Jan 23, 2003·Microscopy Research and Technique·Shozo Yamada, Kouji Takada
Sep 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Tomomi KambaDonald M McDonald
Sep 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Fabienne BaffertDonald M McDonald
Feb 3, 2012·Physiological Reviews·Carolina Perez-CastroEduardo Arzt
Nov 18, 2017·The Oncologist·Manuela Schmidinger, Romano Danesi
Aug 14, 2003·BMC Endocrine Disorders·Alireza Abdollah ShamshirsazBagher Larijani
Oct 23, 2003·Endocrine Reviews·Helen E TurnerJohn A H Wass
Aug 29, 2000·Pediatric Research·D J Hill, B Duvillié
Dec 24, 2018·Expert Opinion on Investigational Drugs·Lea StitzleinRichard Dudley
Sep 1, 2013·EJC Supplements : EJC : Official Journal of EORTC, European Organization for Research and Treatment of Cancer ... [et Al.]·Manuela Schmidinger

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