Immunohistochemical localization of carcinoembryonic antigen as a predictor of lymph node status in submucosa-invasive colorectal carcinoma

Diseases of the Colon and Rectum
N TokunagaT Mitomi

Abstract

Submucosa-invasive colorectal carcinoma is a colorectal carcinoma extending only into the submucosal layer. To clarify the metastatic potential of submucosa-invasive colorectal carcinoma, we studied the relationship between the immunohistochemical staining pattern of carcinoembryonic antigen (CEA) and that of lymphatic invasion/lymph node metastasis. We investigated 49 submucosa-invasive colorectal carcinomas resected surgically or endoscopically. CEA distribution patterns of the neoplastic tissues were divided into three patterns: Pattern 1 = luminal type; Pattern 2 = apical cytoplasmic type; and Pattern 3 = diffuse cytoplasmic type. We also observed the submucosal stromal staining of CEA. Lymphatic invasion and lymph node metastasis were found in 48.8 percent (21/43) and 11.6 percent (5/43) of the Pattern 2/Pattern 3 cases, whereas these were seen in none (0/6) of Pattern 1 cases. Lymphatic invasion and lymph node metastasis were found in 63.3 percent (19/30) (chi-squared = 21.94; P < 0.001) and 16.7 percent (5/30) of the positive stromal CEA cases, whereas these were seen in 10.5 percent (2/19) and none (0/14) of the negative stromal CEA cases, respectively. Pattern 2/Pattern 3 and stromal CEA can be predictors of the lymph ...Continue Reading

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Citations

May 27, 1999·Diseases of the Colon and Rectum·J C KimO J Kim
Nov 12, 2005·Clinical & Experimental Metastasis·Jin C KimJung S Kim
Aug 28, 2002·Gastrointestinal Endoscopy·Takayuki MatsumotoMitsuo Iida
Sep 15, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kwang Soo KimHee Gu Lee
Feb 22, 2002·The Journal of Surgical Research·Klaus GüntherMarc A Reymond
Sep 27, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter JantscheffChristoph Rochlitz
May 26, 2009·Arquivos De Gastroenterologia·Débora Maria NazatoJaques Waisberg
Dec 9, 2010·Arquivos De Gastroenterologia·Denise Gonçalves PriolliJaques Waisberg

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