Immunohistochemical marker panel differentiates between the three most common subtypes of renal cell carcinoma independent from histomorphologic criteria.

Virchows Archiv : an International Journal of Pathology
B WalterC G Stoehr

Abstract

To develop a reliable immunohistochemical marker panel differentiating between the three most common renal cell carcinoma (RCC) subtypes without inclusion of histomorphologic criteria we investigated protein expression of vimentin, glutathione S-transferase alpha (GST-α), CD10, CD117 (C-KIT), carbonic anhydrase 2 (CAII), parvalbumin, alpha-methyl-CoA-racemase (AMACR), and cytokeratin-19 (CK 19) in 65 age and stage matched trios of clear cell carcinoma, papillary renal carcinoma and chromophobe renal carcinoma using tissue microarrays. All markers displayed significant differential expression among the subtypes (p < 0.001) except CAII (p = 0.192). According to positive (LR+) and negative (LR-) likelihood ratio, six markers (CD10, GST-α, AMACR, CK19, C-KIT and arvalbumin) demonstrated acceptable or good values to detect certain subtypes of RCC, but failed in terms of ruling out the respective subtypes. Based on the individual performance of these six markers, we combined them and reviewed each single case: LR+ for detection of clear cell RCC considerably increased by application of the six marker panel, but did not exceed 10. LR- was still >0.1; in case of papillary RCC LR+ rose beyond 10, but LR- remained >0.1. LR+ for recogniti...Continue Reading

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Citations

Feb 13, 2013·Nature Reviews. Gastroenterology & Hepatology·Charles H KnowlesRoberto De Giorgio
Feb 26, 2013·Pathology, Research and Practice·José I López
Feb 26, 2015·Pathology Oncology Research : POR·Hanan AlSaeid Alshenawy
Aug 18, 2018·Disease Markers·Melanie von BrandensteinJochen W U Fries
Apr 1, 2015·Journal of Microscopy and Ultrastructure·Hanan AlSaeid Alshenawy

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