PMID: 7536759Jan 1, 1995Paper

Immunohistochemical observations on the kinetics of macrophages and myofibroblasts in rat renal interstitial fibrosis induced by cis-diamminedichloroplatinum

Journal of Comparative Pathology
J YamateS Sakuma

Abstract

It has been speculated elsewhere that growth factors produced by macrophages in response to tissue damage induce a modulation of pre-existing fibroblasts into myofibroblasts, leading to fibrosis. The development of these cells in cis-diamminedichloroplatinum (CDDP)-induced rat renal interstitial fibrosis was observed immunohistochemically. In the cortico-medullary junction, nuclear changes and epithelial necrosis of the proximal renal tubule (mainly the P3 segment) were seen on days 1 and 4 after a single dose (6 mg/kg body weight) of CDDP, and regenerating epithelium appeared on day 7. Gradually developing fibrosis was observed around the affected tubules on days 14 and 28. The increase in fibrosis was confirmed by histometrical analysis. The number of ED-1 (primary antibody) positive macrophages reached a peak in the affected cortico-medullary junction on day 7 and this was accompanied by an increase in muscle actin-positive myofibroblasts. On days 14 and 28, macrophages had declined in number, but the number of muscle actin-positive myofibroblasts in the fibrotic area was still high as compared with control values. Cytoplasmic myofilaments were observed in myofibroblasts by electron microscopy. These findings suggest that th...Continue Reading

Citations

Jan 25, 2012·Journal of Toxicologic Pathology·Takeki UeharaToshiyuki Maruyama
Jun 11, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Emi KashiwagiJyoji Yamate
Jan 6, 2016·Journal of Clinical Medicine·Anusha H TennakoonJyoji Yamate
Jan 25, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Emi YamamatoJyoji Yamate
Jun 26, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Tao YangGlenda C Gobe
Nov 19, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Kazuhiko SuzukiKunio Doi
Dec 8, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jyoji YamateJonathan LaMarre
Mar 28, 2012·European Journal of Pharmacology·Jeong Woo ParkSoo Wan Kim
Aug 14, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Takahiro YuasaJyoji Yamate
Oct 3, 2018·BioMed Research International·Martina Perše, Željka Večerić-Haler
Oct 3, 2000·Seminars in Dialysis·G Garosi, N Di Paolo
Oct 16, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Abdalkareem Omar MaghmomehNoha Abdel-Rahman
May 1, 2004·Kidney & Blood Pressure Research·Heloísa D Coletta FrancescatoMaria de L P Bianchi
Jan 16, 2009·American Journal of Physiology. Renal Physiology·Hao PanBin Gao

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