Immunohistochemical panel of degenerated articular discs from patients with temporomandibular joint osteoarthritis

Journal of Oral Rehabilitation
Bruno V FernandesJoão C Zielak

Abstract

Temporomandibular joint osteoarthritis (TMJOA) is a progressive degenerative disease caused by imbalance between anabolic and catabolic stimuli. The aim of this study was to evaluate histopathological changes, collagen degeneration and the expression of eleven TMJOA biomarkers in articular discs. Specimens were obtained from eight female patients submitted to discectomy. Discs were divided into anterior band (AB), intermediate zone (IZ) and posterior band (PB) for computerised histomorphometric analyses. Each was assigned a histopathological degeneration score (HDS). Collagen degeneration was assessed with Picrosirius-polarisation method. Biomarkers were evaluated through immunohistochemistry, including IGF-1, OPG, VEGF, TNF-α, FGF-23, IHH, MMP-3, MMP-9, TGF-β1 , BMP-2 and WNT-3. Image processing software was used to calculate average immature collagen ratios and immunostained areas. Spearman rank tests were applied to verify correlations, with significance level of 0.05. The HDS showed negative correlation with expression of VEGF in IZ and PB (P < .05) and positive with TNF-α in AB (P < .01). Collagen degeneration correlated with TGF-β1 (P < .05), BMP-2 (P < .01) and IHH (P < .05) immunostained areas in the IZ; TGF-β1, BMP-2 a...Continue Reading

References

Apr 1, 1989·Archives of Otolaryngology--head & Neck Surgery·C H Wilkes
Aug 4, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H YoshidaT Iizuka
Jan 8, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·T SuzukiT Iizuka
Jun 11, 2002·The British Journal of Oral & Maxillofacial Surgery·T SuzukiT Iizuka
May 24, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Eiji Tanaka, Theo van Eijden
Feb 4, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jun SatoYoshino Yoshitake
Mar 11, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Luis Eduardo AlmeidaSérgio Aparecido Ignácio
Mar 18, 2008·Oral and Maxillofacial Surgery Clinics of North America·Louis G Mercuri
Mar 26, 2008·Journal of Dental Research·E TanakaL G Mercuri
Jul 29, 2008·Connective Tissue Research·Jean-Pierre PujolKarim Boumediene
Jan 19, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Michael Miloro, Brent Henriksen
Nov 26, 2010·Dental Clinics of North America·Jeffrey P Okeson, Reny de Leeuw
Jun 4, 2011·Cell and Tissue Research·Peter M van der KraanPeter ten Dijke
Jul 16, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Raed LattoufSylvie Changotade
Dec 4, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Orhan GüvenEmre Kaymak
Jan 15, 2015·Computer Methods in Biomechanics and Biomedical Engineering·Zhan LiuYubo Fan
Jul 15, 2015·Journal of Medical Imaging·Liliane R GomesLucia Cevidanes
Oct 18, 2015·International Journal of Oral and Maxillofacial Surgery·I M DiasR de S Tesch
Nov 5, 2015·Journal of Dental Research·T E BechtoldE Koyama
Mar 8, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Till E BechtoldEiki Koyama
Sep 21, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ting XuHuiling Wu
Mar 28, 2017·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Flavio de Alcântara CamejoPaula Cristina Trevilatto
Apr 19, 2017·Cells, Tissues, Organs·Maya ShirakuraMarian F Young
Apr 28, 2017·Cranio : the Journal of Craniomandibular Practice·Juliano Henrique PerottoPaula Cristina Trevilatto
Jun 2, 2017·Experimental and Therapeutic Medicine·Jianlin LiuSuwen Wang
Aug 13, 2017·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Michael MiloroMichael R Markiewicz
Jan 13, 2018·Cranio : the Journal of Craniomandibular Practice·Luis Eduardo AlmeidaAndrea Doetzer
Feb 3, 2018·International Journal of Molecular Sciences·Xavier Van BellinghenFlorence Fioretti
Jun 15, 2018·Journal of Bone Metabolism·Peter M van der Kraan
Feb 21, 2019·International Journal of Oral Science·Sheng-Jie CuiXue-Dong Wang
May 3, 2019·Journal of Oral Rehabilitation·Hong-Yun ZhangMei-Qing Wang

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