Immunohistochemical Pitfalls in Genitourinary Pathology: 2018 Update

Advances in Anatomic Pathology
Roni M CoxJesse K McKenney

Abstract

Immunohistochemistry may be a very useful adjunct to morphologic diagnosis in many areas of surgical pathology, including genitourinary pathology. In this review, we address common diagnostic dilemmas where immunophenotypic analysis may be utilized and we highlight pitfalls specific to each scenario. For prostate, we review the diagnosis of limited prostatic adenocarcinoma and the distinction of high-grade prostatic adenocarcinoma from urothelial carcinoma. We also cover markers of urothelial lineage in the diagnosis of metastatic carcinoma of unknown primary site. In the kidney, distinction of poorly differentiated renal cell carcinoma from urothelial carcinoma and epithelioid angiomyolipoma, adjuncts to the recognition of hereditary renal neoplasia, and the diagnosis of metastatic renal cell carcinoma are discussed. Finally, for testis we address distinction of germ cell tumors from sex cord-stromal tumors, as well as the diagnosis of metastatic germ cell tumors.

References

Sep 5, 1998·American Journal of Clinical Pathology·N G Ordóñez
Mar 8, 2000·American Journal of Clinical Pathology·N H BassilyM A Rubin
Dec 6, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·E M GenegaP B Gaudin
Oct 31, 2001·The American Journal of Surgical Pathology·Z JiangG R Fanger
Jul 20, 2002·The American Journal of Surgical Pathology·Ximing J YangZhong Jiang
Sep 10, 2002·The American Journal of Surgical Pathology·Rajal B ShahMark A Rubin
Sep 10, 2002·The American Journal of Surgical Pathology·Zhong JiangXiming J Yang
Dec 3, 2002·The American Journal of Surgical Pathology·R BeachM B Amin
Dec 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael H WeinsteinMassimo Loda
Feb 27, 2003·The American Journal of Surgical Pathology·Ming ZhouMark A Rubin
Mar 28, 2003·The Prostate·Edward P GelmannLukas Bubendorf
Jul 29, 2003·The American Journal of Surgical Pathology·Cristina Magi-GalluzziJonathan I Epstein
Jun 19, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vincent MoliniéAnne C Baglin
Jun 30, 2004·The American Journal of Surgical Pathology·Timothy D JonesLiang Cheng
Aug 19, 2004·The American Journal of Surgical Pathology·Anita GuptaXiming J Yang
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Mar 4, 2006·Seminars in Diagnostic Pathology·Robert E Emerson, Thomas M Ulbright
May 4, 2006·Pathology International·Ping ZhangKennichi Kakudo
Oct 27, 2006·Gynecologic Oncology·Nathan J BowenJohn F McDonald
Nov 1, 2006·American Journal of Clinical Pathology·Brian P Adley, Ximing J Yang
Aug 2, 2007·The American Journal of Surgical Pathology·Ai-Ying ChuangJonathan I Epstein
Aug 28, 2007·The American Journal of Surgical Pathology·Todd SheridanPeter B Illei
Sep 27, 2007·The American Journal of Surgical Pathology·Maria J MerinoWilliam Marston Linehan
Dec 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daisuke NonakaRonald Ghossein
Dec 29, 2007·The American Journal of Surgical Pathology·Christopher G PrzybycinRajal B Shah
Feb 28, 2008·The American Journal of Surgical Pathology·Adeboye O OsunkoyaJonathan I Epstein
Apr 15, 2008·The American Journal of Surgical Pathology·Wenle WangJonathan I Epstein
Aug 30, 2008·Journal of the National Cancer Institute·Christopher RickettsEamonn R Maher
Aug 30, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Chengquan ZhaoRussell Vang
Sep 25, 2008·The American Journal of Surgical Pathology·Tehmina Z Ali, Jonathan I Epstein

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Citations

Jan 15, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alexander S TaylorRohit Mehra
May 2, 2019·Journal of Magnetic Resonance Imaging : JMRI·Emaan AlviKenneth R Shroyer
Jan 7, 2021·Archives of Pathology & Laboratory Medicine·Nicholas BaniakMichelle S Hirsch

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