Immunohistochemical predictive markers of response to conservative treatment of endometrial hyperplasia and early endometrial cancer: A systematic review

Acta Obstetricia Et Gynecologica Scandinavica
Antonio TravaglinoFulvio Zullo

Abstract

Progestogens are widely used for the conservative treatment of endometrial hyperplasia and early endometrial cancer. Nevertheless, they do not achieve the regression in all cases. Although several immunohistochemical markers have been assessed to predict the response to treatment, their usefulness is still unclear. We aimed to analyze the usefulness of each immunohistochemical marker studied in predicting the response to progestogens in endometrial hyperplasia and early endometrial cancer. Electronic databases were searched for relevant articles from January 2000 to June 2018. All studies assessing the association of immunohistochemical markers with the outcome of the progestogen-based therapy in endometrial hyperplasia and early endometrial cancer were included. The expression of immunohistochemical markers in pretreatment phase and changes of expression during the follow-up were evaluated in relation to response to therapy and relapse. Twenty-seven studies with 1360 women were included in the systematic review; 43 immunohistochemical markers were assessed. The most studied predictive markers in the pretreatment phase were progesterone and estrogen receptors, although with conflicting results; their isoforms, and in particular...Continue Reading

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Dec 5, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo

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Citations

Aug 14, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoFulvio Zullo
Sep 19, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo
Aug 25, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneMaurizio Guida
Dec 8, 2019·Pathology Oncology Research : POR·Antonio TravaglinoFulvio Zullo
May 31, 2020·Pathology Oncology Research : POR·Antonio TravaglinoFulvio Zullo
Aug 25, 2019·Pathology Oncology Research : POR·Antonio RaffoneGian Franco Zannoni
Mar 18, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo
Sep 23, 2019·Archives of Gynecology and Obstetrics·Ruggero LionettiFrancesco Corcione
Mar 28, 2019·Archives of Gynecology and Obstetrics·Antonio RaffoneFulvio Zullo
Aug 23, 2019·American Journal of Clinical Pathology·Antonio TravaglinoFulvio Zullo
Jun 17, 2019·Pathology Oncology Research : POR·Antonio RaffoneFulvio Zullo
Jun 27, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio RaffoneFulvio Zullo
Dec 18, 2019·Histopathology·Anthony T Williams, Raji Ganesan
May 10, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Eva BaxterAndreas Obermair
Dec 20, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Antonio TravaglinoFulvio Zullo
Apr 17, 2020·Archives of Gynecology and Obstetrics·Antonio TravaglinoFulvio Zullo
Apr 8, 2020·Archives of Gynecology and Obstetrics·Antonio TravaglinoFulvio Zullo
Sep 19, 2019·Archives of Gynecology and Obstetrics·Antonio TravaglinoFulvio Zullo
Sep 2, 2019·Gynecologic Oncology·Antonio RaffoneFulvio Zullo
Oct 2, 2020·Cancer Prevention Research·Abigail E DerbyshireEmma J Crosbie
Jan 15, 2020·Gynecologic Oncology·Antonio RaffoneFulvio Zullo
Apr 9, 2021·Advances in Therapy·Maria-Eulalia Fernandez-MontoliNayanar-Adela Contreras-Perez
Apr 1, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoLuigi Insabato
Jul 6, 2021·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Luigi Della CorteJan Tesarik
Jul 22, 2021·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Ilker Kahramanoglu
Jul 23, 2021·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·José Carugno, Adriana Wong
Nov 28, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Antonio TravaglinoLuigi Insabato
Jan 7, 2022·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Maria ZisiMinas Paschopoulos

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