Abstract
To describe the main characteristics of women with breast cancer, according to the immunohistochemical profile. The population comprised a hospital cohort, consisting of women diagnosed with breast cancer between 2003 and 2005 (n = 601) and treated at a referral center for cancer care in Juiz de Fora, MG, Brazil. Only 397 women who had complete immunohistochemistry analysis were selected. To define the groups according to the immunohistochemical profile, the assessment of estrogen and progesterone receptors, Ki-67 cell proliferation index, and overexpression of human epidermal growth factor receptor 2 (HER2) was chosen. According to the different phenotypes, five subtypes were defined: luminal A, luminal B HER2 negative, luminal B HER2 positive, triple negative, and HER2 overexpression. Most patients were white (80.7%) and post-menopausal (64.9%), with a mean age of 57.4 years (± 13.5). At diagnosis, 57.5% had tumor size > 2.0 cm, and 41.7% had lymph node involvement. The most common subtypes were luminal B - HER2 negative (41.8%) and triple negative (24.2%). In the luminal A subtype, 72.1% of patients were post-menopausal, while the highest percentage of premenopausal women were observed in the luminal B - HER2 positive and tr...Continue Reading
References
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jul 25, 2003·Expert Review of Molecular Diagnostics·Ronald SimonGuido Sauter
Aug 28, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas C PuttiIan O Ellis
Dec 2, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Therese Sørlie
Apr 2, 2005·Breast Cancer Research and Treatment·William F AndersonSusan S Devesa
Oct 21, 2005·The New England Journal of Medicine·Martine J Piccart-GebhartUNKNOWN Herceptin Adjuvant (HERA) Trial Study Team
Feb 25, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M DowsettM Baum
Mar 1, 2006·Journal of Clinical Pathology·J S Reis-FilhoJ-Y Pierga
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Mar 28, 2007·Cancer·Katrina R BauerVincent Caggiano
Apr 18, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa A CareyCharles M Perou
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca DentSteven A Narod
Oct 4, 2007·Breast Cancer Research : BCR·Bas KreikeMarc J van de Vijver
May 26, 2009·Breast Cancer Research : BCR·Marilyn L KwanBette J Caan
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K David VoducHagen Kennecke
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Aug 14, 2010·Clinical Breast Cancer·Carlos S VallejosCarlos E Vigil
Jan 12, 2011·Journal of Pathology Informatics·Mark C LloydMarilyn M Bui
Feb 10, 2011·The Oncologist·Charles M Perou
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Apr 8, 2011·Cancer·Manfred KaufmannUNKNOWN Biedenkopf Expert Panel Members
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jul 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edith A PerezNorman Wolmark
Nov 2, 2011·The Breast : Official Journal of the European Society of Mastology·Giuseppe Viale
Oct 25, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Geza AcsPaul J Zhang