PMID: 2505201Aug 28, 1989Paper

Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

Neuroscience Letters
E MasliahL A Hansen

Abstract

Alzheimer disease (AD) as well as other dementing disorders are characterized by a continuous loss of neurons in cortical and subcortical areas and probably by an extensive synaptic loss. In order to substantiate and localize the loss of synapses in AD, we quantified by microdensitometry the neuropil immunoreactivity to an antibody that labels the protein synaptophysin (p38), which is localized in the presynaptic terminals. We found in the AD cases an average 50% decrease in the density of the granular neuropil immunoreaction in parietal, temporal and midfrontal cortex. In contrast, Pick disease cases presented close to normal values in parietal cortex, but major losses in temporal and frontal cortex. Our data strongly suggest an important role of synapse loss in dementia.

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Citations

Jun 1, 1991·Annals of Neurology·C A WileyR Terry
Aug 1, 1991·Annals of Neurology·A C McKeeN W Kowall
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Apr 25, 2009·Acta Neuropathologica·Thomas Arendt
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Sep 21, 2012·Acta Neuropathologica·Tobias BittnerJochen Herms
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Nov 23, 1992·Neuroscience Letters·R P StroemerC E Hulsebosch

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