PMID: 11920478Mar 29, 2002Paper

Immunohistochemical staining of GLUT1 in benign, borderline, and malignant ovarian epithelia

Cancer
Tamara KalirDavid E Burstein

Abstract

Aberrant expression of the facilitative glucose transporter GLUT1 is found in a wide spectrum of epithelial malignancies. The authors describe an immunohistochemical study of GLUT1 expression in benign, borderline, and malignant ovarian epithelia. One hundred forty one formalin-fixed, paraffin-embedded sections were immunostained with rabbit anti-GLUT1 using the streptavidin-biotin method. The samples were as follows: 3 endometriotic cysts, 9 serous cystadenomas, 15 mucinous cystadenomas, 17 noninvasive borderline implants, 3 invasive borderline implants, and 3 endosalpingiosis. In addition, 35 borderline tumors (26 serous, 7 mucinous, 2 seromucinous) and 56 adenocarcinomas (50 serous, 4 endometrioid, 2 mucinous) were stained. Benign serous and mucinous cystadenomas and endosalpingiosis were non-staining with GLUT1 antiserum. Twenty-eight of 35 borderline tumors (80%) stained positively, with weak to moderate (1-2+ out of 3) staining intensity and focal or patchy distribution. Seventeen noninvasive serous borderline implants were negatively stained; however, three invasive serous borderline implants were positively stained with GLUT1 antiserum. Fifty four of 56 ovarian carcinomas (96%) stained positively, with moderate to stron...Continue Reading

Citations

Mar 28, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·W Ju, S C Kim
Jan 14, 2011·The Journal of Surgical Research·Laleh G MelstromDavid J Bentrem
Jul 25, 2014·The Journal of Obstetrics and Gynaecology Research·Yu CaiXiao-jin He
Feb 9, 2010·American Journal of Obstetrics and Gynecology·Paul LoarJ Rebecca Liu
Dec 21, 2016·Pathology International·Nazim BenzerdjebHenri Sevestre

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