PMID: 7536179Jan 1, 1995Paper

Immunohistochemical staining patterns of keratins in normal oesophageal epithelium and carcinoma of the oesophagus

Histopathology
H TakahashiA Tsubura

Abstract

To clarify the keratin staining patterns of invasive carcinoma of the oesophagus, 22 cases of formalin-fixed paraffin-embedded surgical specimens were examined immunohistochemically with the labelled streptavidin biotin method using a panel of six different monoclonal anti-keratin antibodies. The antibody reacted adequately when antigen was retrieved in a microwave oven, and the relationship between morphological characteristics and keratin reaction patterns was analyzed in carcinomas and compared with adjacent histologically normal epithelium. In the normal oesophageal epithelium, AE3 and CK8.12 labelled all layer of cells, KS-1A3, E3 and KL1 labelled suprabasal cells, and LL002 selectively labelled the basal cells. In squamous cell carcinomas, AE3, CK8.12, KL1 and LL002 labelled almost all the tumour cells regardless of their differentiation, E3 only labelled keratinized cells, while marked decrease or loss of KS-1A3 staining was seen in all cases examined. Therefore, the characteristic profile of squamous cell carcinoma was a strong and diffuse expression of keratin 14 and 16, strong but localized expression of keratin 17, and loss of keratin 13 expression. Undifferentiated carcinoma totally lacked all keratin reactivity. Th...Continue Reading

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Citations

Aug 17, 1999·International Journal of Cancer. Journal International Du Cancer·M RaidaK Höffken
Apr 3, 2012·Journal of Cancer Research and Clinical Oncology·Ryoji KitamuraSeiji Nakamura
Feb 23, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ya-Feng WangGuo-Zhen Guo
May 7, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Avninder SinghSunita Saxena
Oct 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J H BaertK Ampe
Dec 2, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S O IbrahimA C Johannessen
Jun 15, 2012·Annals of Surgical Oncology·Munenori IdeTetsunari Oyama
May 3, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Aafke H C van RoonDamian J Hussey
Sep 4, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Youssef A Kousa, Brian C Schutte
Jan 8, 2016·Annals of Diagnostic Pathology·Angel Fernandez-Flores
Mar 28, 2017·Journal of Cancer Research and Clinical Oncology·Yurie MikamiTamotsu Kiyoshima
Sep 7, 2018·Virchows Archiv : an International Journal of Pathology·Shatavisha DasguptaSenada Koljenović

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