Immunohistochemical studies of organic anion transporters and urate transporter 1 expression in human salivary gland.

Acta Odontologica Scandinavica
Ryuichi IkarashiAkira Yamaguchi

Abstract

Various substances including uric acid, organic acids and drugs are transported by organic anion transporters (OATs) in the kidney. In addition, a member of the OAT family, urate transporter 1 (URAT1), is involved in the reabsorption of uric acid from the renal tubule. Benzbromarone inhibits URAT1 to block uric acid reabsorption. Our group previously observed higher salivary uric acid levels than serum levels in patients taking benzbromarone, and reported the possible existence of URAT1-like uric acid excretion mechanism in the salivary gland. The purpose of this study was to elucidate the uric acid excretion mechanism in salivary gland tissues using rabbit anti-human OAT1-4 and URAT1 polyclonal antibodies with EnVision(™) system. In the salivary gland, OAT1 was expressed in ductal cells. OAT2 was found in both ductal cells and serous acinar cells and weak expression was also observed in several nuclei. OAT3 expression was observed in serous acinar cells and nuclei and OAT4 was expressed only in ductal cells. URAT1 expression was observed in the cytoplasm of ductal cells and strong punctuate staining was seen in part of the supra-nuclear cytoplasm. The number of cells expressing URAT1 was smaller compared with OATs. In the kidn...Continue Reading

References

Aug 23, 2000·Pflügers Archiv : European journal of physiology·T SekineH Endou
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Tomoki ImaokaYuichi Sugiyama
Mar 18, 2005·Physiology·Matthias A HedigerHitoshi Endou
Jul 28, 2005·Current Opinion in Nephrology and Hypertension·David B Mount
Sep 29, 2005·Clinical and Experimental Nephrology·Atsushi Enomoto, Hitoshi Endou
Jun 16, 2006·Journal of the American Society of Nephrology : JASN·Karen L PriceRichard J Johnson
Jan 19, 2007·Journal of the American Society of Nephrology : JASN·Yohannes HagosAndrew Bahn
Jul 27, 2007·Nature Clinical Practice. Nephrology·Sanjay K NigamVibha Bhatnagar
Dec 6, 2007·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Atsushi Enomoto, Toshimitsu Niwa
Nov 6, 2007·Journal of the American Society of Nephrology : JASN·Yohannes HagosGerhard Burckhardt
Apr 16, 2008·The Journal of Biological Chemistry·Andrew BahnGerhard Burckhardt
Aug 15, 2008·The Journal of Biological Chemistry·Naohiko AnzaiHiroyuki Sakurai
Oct 25, 2008·Arthritis Research & Therapy·Alexander So
Nov 26, 2008·American Journal of Human Genetics·Hirotaka MatsuoNariyoshi Shinomiya
Aug 21, 2009·Lancet·Pascal Richette, Thomas Bardin
Mar 2, 2010·Biological & Pharmaceutical Bulletin·Masanobu SatoIkumi Tamai

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Citations

Apr 24, 2016·Current Rheumatology Reports·David HyndmanJeffrey N Miner
Jan 8, 2019·Journal of Analytical Toxicology·Lina Dorthea BruunGudrun Høiseth
Nov 23, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hong ShenA David Rodrigues
Oct 2, 2019·International Journal of Molecular Sciences·Joanna Lapczuk-RomanskaMarek Drozdzik
Oct 23, 2015·Journal of Experimental & Clinical Cancer Research : CR·Bojiang ChenWeimin Li
Mar 16, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Shancai TanLin Tang
Oct 14, 2020·The Korean Journal of Internal Medicine·Yousuf WaheedDong Sun
Sep 9, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Aarthi SundararajanSenthilkumar Natesan

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