Immunohistochemical studies of sensory neurons in rat olfactory epithelium

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
C C HuangT Y Huang

Abstract

The olfactory sensory neurons undergo continuous turnover under normal physiological conditions. Injured olfactory sensory neurons are also replaceable. In this study, we investigated cellular differentiation and growth of sensory neurons in the rat's olfactory epithelium after nerve transection by using immunohistochemical staining with polyclonal or monoclonal anti-olfactory marker protein (OMP), anti-c-jun protein and anti-p53 protein antibodies. OMP is found exclusively in olfactory sensory neurons, while c-jun functions as a transcription factor. p53 protein functions as a negative regulator of cellular proliferation related to the apoptotic pathway induced by DNA damage. The olfactory epithelium sections incubated with anti-OMP antibody showed staining of mature neurons and axons in the epithelium. Nerve transection resulted in a significant reduction in neurons labelled with OMP. On the 9th day after operation, our study indicated some recovery with an increasing number of neurons expressing OMP. In control animals without nerve lesions, c-jun protein immunoreactive neurons were present in the olfactory epithelium adjacent to the basal region. Following days 1 and 3 after nerve transection, no expression of c-jun protein...Continue Reading

Citations

Jun 7, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zahidul IslamJames J Pestka
Sep 29, 2011·International Journal of Molecular Sciences·Kunio Doi, Koji Uetsuka
May 11, 2011·Journal of Neuroendocrinology·M-C LacroixF Renaud
Mar 10, 2000·Journal of Neurotrauma·N SaitoT Kumagai

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