PMID: 6171625Dec 1, 1981Paper

Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine

Journal of Neurocytology
G JancsôM Brown

Abstract

After neonatal treatment of rats with capsaicin, the spinal cord, the spinal trigeminal nucleus and spinal and trigeminal ganglia were analysed with immunohistochemistry using antisera to several peptides and 5-hydroxytryptamine. A marked decrease was observed in substance P-, cholecystokinin-, somatostatin- and VIP-like immunoreactivity present in the central branches of primary sensory neurons in the spinal cord and in substance P- and somatostatin-like immunoreactivity in sensory ganglion cells. No definite depleting effect of capsaicin could be established on 5-hydroxytryptamine and peptides, such as enkephalin and neurotensin, present in centrally originating fibres in the dorsal horn of the spinal cord. The results demonstrate that the effects of capsaicin are not confined to substance P immunoreactive primary sensory neurons. The possibility is discussed that capsaicin effects specifically functioning rather than chemically specific primary sensory neurons.

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·M Otsuka, T Takahashi
Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Aug 3, 1979·Cell and Tissue Research·C Burnweit, W G Forssmann
Aug 18, 1978·Brain Research·T M JessellA C Cuello
Sep 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R GamseF Lembeck
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J E MullerR S Yalow
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P RobberechtJ J Vanderhaeghen
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltG Nilsson
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G R UhlS H Snyder
Dec 1, 1978·Acta Physiologica Scandinavica·J M LundbergS Said
Mar 15, 1979·The Journal of Comparative Neurology·R P BarberS E Leeman
Apr 1, 1979·Journal of Neurochemistry·J F Rehfeld, N R Goltermann
Jul 6, 1979·Brain Research·E TheriaultT Jessell
Aug 13, 1979·Life Sciences·R GamseF Lembeck
Oct 15, 1979·European Journal of Pharmacology·P HolzerF Lembeck
Sep 1, 1978·Metabolism: Clinical and Experimental·A ArimuraC Meyers
Mar 25, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·J SzolcsányiF JOO
Sep 23, 1975·Brain Research·G Grant, J Arvidsson
Aug 1, 1975·Acta Physiologica Scandinavica·G NilssonK Folkers
May 1, 1974·Journal of Steroid Biochemistry·H Vetter, W Vetter
Nov 29, 1973·Experimental Brain Research·E Knyihár, M A Gerebtzoff
Jan 1, 1973·Histochemie. Histochemistry. Histochimie·T HökfeltT H Joh
Sep 1, 1967·British Journal of Pharmacology and Chemotherapy·N JancsóJ Szolcsányi
Mar 31, 1980·Brain Research·J I NagyH I Yamamura

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Citations

Feb 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·O D HottensteinE D Jacobson
Jan 1, 1988·Psychopharmacology·M Hajós, G Engberg
Jul 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·H TraurigF Lembeck
Jul 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·Z RózsaV Varró
Sep 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·H TraurigF Lembeck
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·A HaraK Kisara
Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·R Gamse
Mar 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·G SkofitschF Lembeck
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·J M LundbergA Anggård
Nov 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, G Skofitsch
Mar 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·G Jancsó, G Such
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y HamadaJ M Polak
Jan 1, 1986·Journal of Neural Transmission·M HajósA Carlsson
Aug 10, 2012·Pflügers Archiv : European journal of physiology·Mária DuxGábor Jancsó
May 23, 1983·Brain Research·P Stanzione, W Zieglgänsberger
Nov 13, 1984·European Journal of Pharmacology·M YanagisawaM Otsuka
Nov 7, 1989·European Journal of Pharmacology·L MantelliF Ledda
Mar 14, 1989·European Journal of Pharmacology·U Holzer-PetscheF Lembeck
Feb 1, 1986·Journal of the Neurological Sciences·A LjungdahlR Ziegler
Jan 1, 1988·Pharmacology & Therapeutics·L A Chahl
Dec 1, 1984·Brain Research·L C Russell, K J Burchiel

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