Immunohistochemical study for IgG4-positive plasmacytes in pituitary inflammatory lesions.

Endocrine Pathology
Hiroshi NishiokaJo Haraoka

Abstract

On histology, IgG4-related hypophysitis is essentially similar to lymphocytic hypophysitis besides massive IgG4-positive plasmacyte infiltration. This immunohistochemical study was performed to investigate the presence of IgG4-positive plasmacytes in 14 various inflammatory lesions. Five cases of lymphocytic hypophysitis and a case of granulomatous hypophysitis were either negative or showed only a few IgG4-postive cells. A case of hypophysitis associated with pachymeningitis and a case of pituitary invasion of lymphoma were IgG4 negative. On the other hand, some IgG4-positive cells that tended to accumulate were observed in every six cases of secondary inflammation. In conclusion, immunohistochemistry for IgG4 can be a clue for differentiating IgG4-related hypophysitis from lymphocytic hypophysitis. However, clusters of IgG4-positive plasmacytes could be observed in secondary inflammation. Diagnosing hypophysitis with small biopsy specimen still remains troublesome.

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Citations

Mar 15, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hirofumi HiranoKazunori Arita
Aug 23, 2011·Journal of Neurosurgery·Eui Hyun KimJong Hee Chang
Nov 3, 2017·Internal Medicine·Hisashi KoideTomoaki Tanaka
Jul 14, 2017·Clinical Diabetes and Endocrinology·Alexander Faje
Apr 14, 2021·Journal of the Neurological Sciences·G Saitakis, B K Chwalisz

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