PMID: 8615081Jan 1, 1995Paper

Immunohistochemical study of apolipoprotein E in human cerebrovascular white matter lesions

Acta Neuropathologica
H TomimotoH Budka

Abstract

In the brains of ine cases with cerebrovascular disease, one with mixed dementia, one with amyloid angiopathy and two non-neurological controls, we found three cases with focal accumulation of apolipoprotein E (apo-E) in dystrophic axons and accompanying macrophages. Since amyloid precursor protein (APP) and chromogranin A (CgA) accumulate after axonal damages, and are sensitive markers of the white matter lesions, the regional distribution of apo-E was compared to that of APP and CgA. apo-E-immunoreactive axons were present in the periphery of an infarction with neighboring macrophages, but not in mild white matter lesions that contained APP- or CgA-immunoreactive fiber bundles. The results suggest a role of apo-E in recycling cholesterol and other membrane components via macrophages into remodeling neurites in the brain, but this phenomenon is restricted to the periphery of infarction and may be less prominent than in the peripheral nervous system.

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Citations

Apr 26, 2003·Arquivos de neuro-psiquiatria·Dorotéia R S SouzaWaldir A Tognola
Mar 13, 1999·The Journal of Biological Chemistry·S L SaboJ D Buxbaum
Jul 1, 1997·Stroke; a Journal of Cerebral Circulation·I AkiguchiH Budka
Mar 22, 2003·Stroke; a Journal of Cerebral Circulation·Kazuko AokiYoshihiro Wakayama

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