Immunohistochemical study of caveolin-1 and -2 in the rat retina.

Journal of Veterinary Science
Heechul KimTaekyun Shin

Abstract

The expression of caveolin-1 and -2 in the retina was examined; Western blot analysis showed that both were present. Immunohistochemistry indicated that caveolin-1 was expressed in the majority of retinal layers, including the ganglion cell layer, inner plexiform layer, outer plexiform layer, and in the vascular endothelial cells of the retina. Caveolin-2 was primarily immunostained in the vessels, but in a few other elements as well. This is the first demonstration of caveolin differential expression in the retina of rats, and suggests that caveolin plays an important role in signal transduction in glial cells and neuronal cells.

References

Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P E SchererM P Lisanti
Oct 29, 2004·The American Journal of Pathology·Milene Russelakis-CarneiroClaudio Soto
Dec 2, 2004·Journal of Molecular Biology·Richard M EpandRaquel F Epand
Feb 3, 2005·Journal of Neurochemistry·Sophie B GaudreaultJudes Poirier

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Citations

Mar 17, 2009·Experimental Eye Research·Ingeborg KlaassenReinier O Schlingemann
Aug 11, 2012·Biochimica Et Biophysica Acta·Vivek K GuptaStuart L Graham
Aug 8, 2007·Journal of Veterinary Science·Agnes I BertaAgoston Szél

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Methods Mentioned

BETA
electrophoresis

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Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

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