PMID: 7031977Sep 1, 1981Paper

Immunohistochemical study of collagen types in human foetal lung and fibrotic lung disease

Thorax
E D BatemanB C Adelmann-Grill

Abstract

Highly purified type-specific anti-collagen antibodies (prepared in animals to types I, II, III, and IV bovine collagen) were used in an indirect immunofluorescence method for the study of human lung collagen. The tissue localisation of each collagen type, and the apparent type I:III collagen ratio was assessed in normal foetal and adult lung and in fibrotic lung lesions. In the latter, the relationship of the findings to the natural history of the lesion was considered. This method was compared with routine connective tissue stains. The following observations were made. (1) Foetal lung in the canalicular phase of development proved a useful substrate for validating and standardizing the procedure. (2) Collagen fluorescence was more sensitive than connective tissue stains in detecting collagen in foetal tissues and sites of early fibrosis. (3) On the basis of collagen-type fluorescence, two distinctive patterns of fibrosis were recognised. Areas of mature collagen surrounding vessels and bronchi and in established scar tissue, for example in asbestotic pleural plaques, were virtually exclusively type I collagen. By contrast, areas of early active fibrosis like sarcoid nodules and organising pneumonia, which usually contained va...Continue Reading

References

Mar 1, 1975·The Journal of Clinical Investigation·K BradleyR G Crystal
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H B BensusanL A Culp
Aug 1, 1977·Developmental Biology·K von der MarkR L Trelstad
Jan 1, 1978·International Archives of Allergy and Applied Immunology·G WickR Timpl
Apr 1, 1978·Hoppe-Seyler's Zeitschrift für physiologische Chemie·H U SchulzeL Pop
Jun 1, 1978·The Journal of Experimental Medicine·E EngvallE J Miller
Jun 1, 1976·The Journal of Clinical Investigation·J M SeyerA H Kang
Jan 25, 1977·Biochemistry·B D McLeesS R Pinnell
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·G KentH Popper
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S GayK Kuhn
Jan 1, 1975·International Archives of Allergy and Applied Immunology·G WickR Timpl
Oct 27, 1975·Biochemical and Biophysical Research Communications·A J BaileyS bazin
Jan 27, 1972·The New England Journal of Medicine·M E Grant, D J Prockop
Jan 1, 1973·International Review of Connective Tissue Research·M ChvapilW Van Winkle
Dec 1, 1973·Journal of Immunological Methods·B C AdelmannK Hopper
Jun 8, 1973·Biochemical and Biophysical Research Communications·T F LinsenmayerJ Gross
Oct 6, 1972·Biochemical and Biophysical Research Communications·P H Mäenpää, J Ahonen

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Citations

Apr 1, 1986·Clinical & Experimental Metastasis·F W OrrL Young
Jan 1, 1995·International Archives of Occupational and Environmental Health·R P SchinsP J Borm
Jan 1, 1994·International Archives of Occupational and Environmental Health·T H JornaE F Wouters
Mar 8, 2006·Journal of Molecular Histology·Riitta Kaarteenaho-WiikPaavo Pääkkö
Nov 1, 1985·The American Journal of Pathology·M el-TorkeyM Dabbous
Jun 6, 2000·Toxicology·B E Van HoozenJ A Last
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·R P MarshallG J Laurent
Dec 1, 1988·British Journal of Industrial Medicine·A CavalleriA Ziccardi
Jul 1, 1984·Thorax·M M WagnerJ C Wagner
Jun 1, 1986·Thorax·G J Laurent
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·L LammiV Kinnula
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·H S AlhoA L Harjula
Oct 1, 1989·The American Review of Respiratory Disease·P A Coulombe, M Bendayan
Dec 1, 1989·The American Review of Respiratory Disease·C KuhnJ A McDonald
Sep 11, 1992·The American Review of Respiratory Disease·R B LowG S Davis
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Peter M KreinBrent W Winston
Oct 1, 1991·American Journal of Respiratory Cell and Molecular Biology·F R FrankelG Weinbaum
Jul 1, 1985·The Journal of Clinical Investigation·S H PhanD Smith
Apr 1, 1994·The Journal of Clinical Investigation·D J TorryJ Gauldie
Mar 15, 1997·The Journal of Clinical Investigation·J A Cairns, A F Walls
Dec 2, 2010·Respiratory Research·Terttu HarjuRiitta Kaarteenaho
Dec 1, 1991·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·J KropfH Lennartz
Apr 10, 2014·American Journal of Respiratory and Critical Care Medicine·Catherine W M OngJon S Friedland
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M AbeH Kido
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A Cairns
Jan 1, 1992·Experimental Lung Research·Y M JanssenP J Borm
Jan 1, 1986·Experimental Lung Research·R H Goldstein, A Fine
Mar 1, 1997·Experimental Lung Research·P L Sannes, J Wang
Jul 17, 2012·Chest·Chandru HanumegowdaMartin Kolb
Jan 1, 1987·Progress in Histochemistry and Cytochemistry·C Meban
Feb 1, 1990·Pathology, Research and Practice·A Fisseler-EckhoffK M Müller
Sep 19, 2014·Scientific Reports·Kristina Rydell-TörmänenGunilla Westergren-Thorsson
Mar 30, 2016·The American Journal of Pathology·Stephan W GlasserWilliam D Hardie

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