Immunohistochemical study of PTEN and phosphorylated mTOR proteins in familial and sporadic invasive breast carcinomas

Histopathology
Panagiotis BakarakosLydia Nakopoulou

Abstract

Loss of phosphatase and tensin homologue (PTEN) leads to activation of several kinases, including mammalian target of rapamycin (mTOR), which promotes cell cycle progression. The aim was to study the expression of PTEN and phosphorylated (p)-mTOR in familial and sporadic invasive breast carcinomas and their relation to clinicopathological features, molecular indices (Wnt1) and patients' survival. PTEN and p-mTOR were detected immunohistochemically in 215 sections of invasive breast carcinomas (112 with a familial history of breast cancer). Image analysis was used and univariate and multivariate analyses employed for statistical evaluation of results. PTEN was detected in the nucleus (73.5%) and p-mTOR in the cytoplasm (44.2%) of cancer cells. Loss of PTEN protein was more frequently detected in women with a familial history of breast cancer (72%) (P < 0.0001), while its expression was negatively correlated with Wnt1, in total (P = 0.049). p-mTOR showed a positive association with lymph node status (P = 0.010) and was found to have a negative impact on patients' overall survival (P = 0.016). Loss of PTEN protein expression appears to occur more frequently in women with a family history of breast cancer, whereas activation of mTO...Continue Reading

References

Mar 22, 2003·Lancet·Angelo M DeMarzoJonathan I Epstein
Aug 7, 2003·Current Opinion in Pharmacology·Shile Huang, Peter J Houghton
Aug 26, 2003·Human Mutation·Charis Eng
Apr 29, 2004·Journal of Clinical Pathology·L NakopoulouA Keramopoulos
Jun 15, 2004·Cancer Cell·Lora Hedrick Ellenson, T-C Wu
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaoyan ZhouDihua Yu
Nov 24, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Ji Shin LeeKyung Whan Min
Jul 9, 2005·Trends in Molecular Medicine·David A Guertin, David M Sabatini
Dec 13, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shikha BoseNamrata Bose
Jan 18, 2006·Cancer Letters·Lionel M L Chow, Suzanne J Baker
May 17, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christopher A HaimanMatthew L Freedman
Aug 11, 2006·Journal of Mammary Gland Biology and Neoplasia·Nancy E Hynes, Anne Boulay
Jun 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gizeh Pérez-TenorioOlle Stål
Aug 8, 2007·Cell Research·Qian Yang, Kun-Liang Guan

❮ Previous
Next ❯

Citations

Dec 18, 2012·Breast Cancer Research and Treatment·Josefine BostnerOlle Stål
Nov 26, 2013·The Journal of Clinical Investigation·Shu-Chen LiuYu-Sun Chang
Feb 16, 2015·Pathology Oncology Research : POR·Tomofumi NaruseMasahiro Umeda
Feb 12, 2015·Journal of Comparative Pathology·L DelgadoP Dias Pereira
Apr 23, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Luís Silva MonteiroCarlos Lopes
Jul 24, 2014·Journal of Clinical Pathology·Francisco BecaFernando Schmitt
Sep 11, 2019·Cold Spring Harbor Perspectives in Medicine·Rafael PulidoJosé I López
Jan 14, 2020·Journal of Oncology·Yunseo WooYu-Jin Jung
May 1, 2018·European Journal of Human Genetics : EJHG·Janire MingoRafael Pulido
Jan 19, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chandra B LebovitzSharon M Gorski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Related Papers

The Breast : Official Journal of the European Society of Mastology
S WalshM J Duffy
Annals of Oncology : Official Journal of the European Society for Medical Oncology
C Villarreal-GarzaS Verma
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Xiaoyan ZhouDihua Yu
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Shikha BoseNamrata Bose
© 2021 Meta ULC. All rights reserved