Immunohistochemical study of vasoactive intestinal peptide (VIP) enteric neurons in diabetic rats supplemented with L-glutamine

Nutritional Neuroscience
Eder Paulo Belato AlvesJacqueline Nelisis Zanoni

Abstract

The purpose of this work was to study the area of the varicosities of nerve fibers of myenteric neurons immunoreactive to vasoactive intestinal peptide (VIP-IR) and of the cell bodies of VIP-IR submucosal neurons of the jejunum of diabetic rats supplemented with 2% L-glutamine. Twenty male rats were divided into the following groups: normoglycemic (N), normoglycemic supplemented with L-glutamine (NG), diabetic (D) and diabetic supplemented with L-glutamine (DG). Whole-mounts of the muscle tunica and the submucosal layer were subjected to the immunohistochemical technique for neurotransmitter VIP identification. Morphometric analyses were carried out in 500 VIP-IR cell bodies of submucosal neurons and 2000 VIP-IR varicosities from each group. L-Glutamine supplementation to the normoglycemic animals caused an increase in the areas of the cell bodies (8.49%) and varicosities (21.3%) relative to the controls (P < 0.05). On the other hand, there was a decrease in the areas of the cell bodies (4.55%) and varicosities (28.9%) of group DG compared to those of group D (P < 0.05). It is concluded that L-glutamine supplementation was positive both to normoglycemic and diabetic animals.

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Citations

Oct 24, 2013·World Journal of Gastroenterology : WJG·Paulo Emilio Botura FerreiraNilza Cristina Buttow
Dec 29, 2013·Digestive Diseases and Sciences·Catchia Hermes-UlianaJacqueline Nelisis Zanoni
Jun 29, 2011·Digestive Diseases and Sciences·Renata Virginia Fernandes PereiraJacqueline Nelisis Zanoni
Feb 24, 2016·Experimental Parasitology·Marcelo Biondaro GóisDébora de Mello Gonçales Sant'Ana
Nov 4, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L FracaroJ N Zanoni
Oct 5, 2015·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Cristiano Massao TashimaJacqueline Nelisis Zanoni
Jun 17, 2015·Digestive Diseases and Sciences·Aline Cristine da Silva de SouzaNilza Cristina Buttow
Jul 19, 2012·International Journal of Experimental Pathology·Débora M G Sant'AnaEduardo J A Araújo
Aug 15, 2012·Nutritional Neuroscience·Priscila de FreitasMarcilio Hubner de Miranda Neto
Dec 7, 2010·Regulatory Peptides·Guo-Ying SunXiang Fang
Jul 30, 2016·Acta histochemica·Cynthia Priscilla do Nascimento Bonato PanizzonMarcílio Hubner de Miranda Neto
Mar 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Heber Amilcar MartinsJacqueline Nelisis Zanoni
Aug 29, 2019·Arquivos De Gastroenterologia·Jacqueline Nelisis Zanoni, Gleison Daion Piovezana Bossolani
May 7, 2015·World Journal of Gastroenterology : WJG·Eduardo José de Almeida AraújoDébora de Mello Gonçales Sant'Ana
May 5, 2016·Anais Da Academia Brasileira De Ciências·Renata V F PereiraJacqueline N Zanoni

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