Immunohistochemical verification of ductal differentiation in prostate cancer

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Miklós TarjánTibor Tot

Abstract

Recent studies have shown that patients with prostate carcinomas exhibiting ductal differentiation have an unfavourable prognosis compared with those with purely acinar adenocarcinomas. We studied the expression of nine immunohistochemical markers to evaluate their value in delineating carcinomas with and without ductal differentiation. Thirteen tumours showing cellular characteristics and growth patterns typical of ductal differentiation were identified among 110 analysed prostatectomy specimens. The levels of cytoplasmic expression of chromogranine A (69% vs 19%, p = 0.0003) and nuclear expression of p53 (76% vs 12%, p < 0.0001) as well as nuclear expression of Ki-67 (69% vs 26%, p = 0.0047) in the tumour cells, were found to be statistically significantly different in the two tumour categories. Assessment of chromogranine A, p53 and Ki-67 in prostate carcinoma may serve as useful adjunctive diagnostic tools for delineating more aggressive prostate cancer cases exhibiting ductal differentiation.

References

Apr 15, 1991·Cancer·W N ChristensenJ I Epstein
Aug 1, 1985·The American Journal of Surgical Pathology·D G BostwickR V Rouse
Oct 1, 1967·Cancer·M M Melicow, M R Pachter
Mar 24, 1999·International Journal of Oncology·X Z BaiM C Parkinson
Jul 14, 1999·The American Journal of Surgical Pathology·B J Bock, D G Bostwick
Mar 8, 2000·American Journal of Clinical Pathology·N H BassilyM A Rubin
Jul 31, 2002·The Lancet Oncology·Shi-Ming TuChristopher J Logothetis
Sep 24, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Ozden TulunayYusuf Z Müftüoglu
Jul 16, 2005·Scandinavian Journal of Urology and Nephrology. Supplementum·Mahul AminRodolfo Montironi
Jul 25, 2006·The American Journal of Surgical Pathology·Ecaterina F Tamas, Jonathan I Epstein
Nov 30, 2006·Scandinavian Journal of Urology and Nephrology·M Tarján, T Tot
Jun 17, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thorsten SchlommAndreas Erbersdobler
Dec 10, 2009·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Jonathan I Epstein

❮ Previous
Next ❯

Citations

Jul 26, 2014·Virchows Archiv : an International Journal of Pathology·Amanda H SeipelLars Egevad
Aug 10, 2017·Journal of Pathology and Translational Medicine·Se Un JeongYong Mee Cho
Apr 1, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Ali Amin
Mar 9, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ken ChowNiall M Corcoran
Apr 8, 2021·Nature Reviews. Urology·Weranja RanasingheBrian F Chapin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.