PMID: 11920523Mar 29, 2002Paper

Immunohistochemically detected hepatic micrometastases predict a high risk of intrahepatic recurrence after resection of colorectal carcinoma liver metastases

Cancer
Naoyuki YokoyamaKatsuyoshi Hatakeyama

Abstract

Hepatic metastases from colorectal carcinoma frequently recur after resection and hepatic micrometastases most likely are important in the development of such recurrences. The objectives of the current study were to assess the feasibility of the immunohistochemical detection of hepatic micrometastases from colorectal carcinoma and to determine their clinical significance. Fifty-three patients underwent curative hepatic resection for colorectal carcinoma metastases. Multiple tissue sections were cut from the advancing margin of the largest hepatic metastasis in each patient and were stained with an antibody against cytokeratin-20 to detect hepatic micrometastases, which were defined as discrete microscopic cancerous lesions surrounding the dominant metastasis. Normal hepatocytes and intrahepatic bile duct epithelia stained negative for cytokeratin-20 in all patients, whereas the largest hepatic tumors stained positive in 46 patients (86.8%). Among the 46 patients with hepatic tumors that were positive for cytokeratin-20, hepatic micrometastases were found immunohistochemically in 32 patients (69.6%). The presence of hepatic micrometastases was associated with a larger number of macroscopic hepatic metastases (P = 0.047) and pati...Continue Reading

References

Jan 1, 1996·British Journal of Cancer·M A McGuckinR G Wright
Jan 1, 1996·Surgery·J ScheeleA Altendorf-Hofmann
Apr 8, 1998·Journal of Surgical Oncology·R CalaluceY W Yesus
Aug 11, 1998·Surgery Today·M NankoM Hara
Sep 25, 1998·World Journal of Surgery·T KinH Nakano
May 27, 1999·Diseases of the Colon and Rectum·S AmbiruN Nakajima
Sep 3, 1999·Journal of the American College of Surgeons·S IwatsukiT E Starzl
Jan 15, 2000·Annals of Surgery·H UenoT Yamamoto
Dec 21, 2000·The British Journal of Surgery·M R KellH P Redmond
Aug 9, 2001·Journal of the American College of Surgeons·S NagakuraK Hatakeyama

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Citations

Oct 2, 2004·International Journal of Colorectal Disease·Michael ConzelmannMartin R Berger
Nov 30, 2006·International Journal of Colorectal Disease·Christoph IsbertChristoph-T Germer
Apr 11, 2009·Journal of Hepato-biliary-pancreatic Surgery·Takashi NomuraWataru Kimura
May 21, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hiroyuki YoshidomeMasaru Miyazaki
Dec 22, 2006·Nature Clinical Practice. Oncology·Martin J Slade, R Charles Coombes
May 29, 2004·The American Journal of Surgical Pathology·David K McGregorStanley R Hamilton
Nov 21, 2013·Annals of Surgery·Klaas M GovaertInne H M Borel Rinkes
Mar 13, 2008·Annals of Surgical Oncology·Jarmila D W van der BiltInne H M Borel Rinkes
Jan 30, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·K M GovaertI H M Borel Rinkes
May 23, 2012·Current Colorectal Cancer Reports·Klaas M GovaertInne H M Borel Rinkes
Apr 23, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L De CarlisK Bencardino
Oct 5, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Anders R KnudsenFrank V Mortensen
Jun 23, 2006·Neoplasia : an International Journal for Oncology Research·Sharon Moshitch-MoshkovitzIlan Tsarfaty
Feb 1, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K TanakaI Endo
Nov 21, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M W NijkampI H M Borel Rinkes
Mar 8, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A SerrabloC Hörndler
Sep 30, 2015·Cancer Treatment Reviews·René AdamUNKNOWN of the EGOSLIM (Expert Group on OncoSurgery management of LIver Metastases) group
Nov 10, 2012·International Journal of Experimental Pathology·Léon MaggioriYves Panis
Aug 29, 2006·The Journal of Surgical Research·Lars FrichIvar P Gladhaug
Jul 4, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C P NealD P Berry
Aug 30, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M ConzelmannM R Berger
Apr 16, 2015·European Journal of Gastroenterology & Hepatology·Doenja M J LambregtsRegina G H Beets-Tan
Oct 22, 2016·ANZ Journal of Surgery·Gholamreza MohajeriAlireza Mohammadi
Oct 18, 2016·Expert Review of Anticancer Therapy·Axel AndresChristian Toso
Feb 16, 2018·Journal of Surgical Oncology·Gilton M FonsecaPaulo Herman
Mar 23, 2018·Scientific Reports·Shivani PahwaVikas Gulani
Oct 27, 2018·World Journal of Gastrointestinal Oncology·Emilio De RaffeleFrancesco Minni
Jan 8, 2005·World Journal of Gastroenterology : WJG·Xi-Wei ZhangGuo-Yu Chen
Jun 28, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Luca ViganòGuido Torzilli
Mar 22, 2014·Molecular and Clinical Oncology·Yoshito AkagiKazuo Shirouzu

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