PMID: 9179061Jun 1, 1997Paper

Immunohistochemically detected p53 and HER-2/neu expression and nuclear DNA content in familial epithelial ovarian carcinomas

Cancer
A AuranenP J Kleml

Abstract

Some epithelial ovarian carcinomas tend to occur more frequently in certain families. This clustering may be due to a genetic predisposition, but the role of inherited susceptibility in all families with multiple cases of ovarian carcinoma is currently unresolved. Studies characterizing familial ovarian carcinomas are few. From a population-based study of 559 patients with epithelial ovarian carcinoma, 27 families with 2 or more ovarian carcinoma cases occurring in first-degree relatives were identified. Histopathology, ploidy, and immunohistochemically detected p53 and HER-2/neu expression in these tumors were examined. The mean age of the patients with familial ovarian carcinoma was 56.7 years. Approximately 67% of the tumors were either serous or undifferentiated adenocarcinomas. The percentage of aneuploid tumors was 46%, that of p53 positive tumors was 51%, and that of HER-2/neu positive tumors was 69%. When the families were divided into families with cases of breast carcinoma in addition to ovarian carcinoma cases and/or ovarian carcinoma in 2 consecutive generations (12 families) and families with ovarian carcinoma occurring in sisters only without cases of breast carcinoma (15 families), no differences were noted in th...Continue Reading

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Citations

Jan 10, 2014·Molecular Diagnosis & Therapy·Henry D ReyesKimberly K Leslie
Feb 23, 2008·Biochimica Et Biophysica Acta·Jacqueline M LafkyNita J Maihle
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Feb 18, 2006·Cancer Treatment Reviews·Alberto Serrano-OlveraJaime De la Garza-Salazar
Nov 28, 2014·Asia-Pacific Journal of Clinical Oncology·Morteza AghmeshehFarshid Niknam

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