Immunohistochemistry in the Diagnosis of Hepatocellular Carcinoma.

Gastroenterology Clinics of North America
Won-Tak Choi, Sanjay Kakar

Abstract

Hepatocellular carcinoma (HCC) can be difficult to distinguish from its mimics, including metastatic tumor, benign hepatocellular lesion, and high-grade dysplastic nodule, especially when limited biopsy material is available. Hence, the judicious use of immunohistochemical stains is necessary to establish a correct diagnosis. This article describes advantages and disadvantages of immunohistochemical markers that are most commonly used to distinguish between these lesions. Diagnostic workup of malignant liver mass (HCC and its histologic variants vs metastatic tumor) as well as well-differentiated hepatocellular lesion (well-differentiated HCC vs focal nodular hyperplasia vs hepatocellular adenoma) is also discussed.

Citations

Sep 8, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Khalid AminMahmoud A Khalifa
Jan 10, 2020·Environmental Science and Pollution Research International·Ehab ToussonThulfiqar Fawwaz Mutar
Jan 9, 2021·Environmental Science and Pollution Research International·Mabrouk Attia Abd EldaimAbdullah A S Ahmed
Nov 13, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Vaidehi AvadhaniAlyssa Krasinskas
May 8, 2021·World Journal of Hepatology·Mukul Vij, Julien Calderaro
Aug 31, 2021·Diagnostic Cytopathology·Susan Shyu, Syed Z Ali
Oct 7, 2021·Journal of Clinical Laboratory Analysis·Ting WangShao Zhou

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