PMID: 7541147Jan 1, 1995Paper

Immunohistochemistry of eccrine poroma and porocarcinoma--more than acrosyringeal tumors?

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer
U WollinaD Rulke

Abstract

Sweat gland tumors have been classified according to their presumed physiological counterpart of the sweat apparatus. Both benign poroma and malignant porocarcinoma are thought to be acrosyringeal tumors. In order to specify this general assumption, we performed histochemistry and immunohistochemistry on paraffin sections of 29 poromas and eight porocarcinomas. In detail, we used Lapham's stain, Masson's silver impregnation, and immunoperoxidase staining with glandular marker antibodies against glycoproteins (CEA, LS59, NKI/C-3) and intermediate filament proteins (wide spectrum keratin, Cam 5.2, Vim 9(1)). Poromas disclosed some scattered S100-positive dendritic cells, red-stained cells in Lapham's method, several silver impregnated dendritic cells, and numerous cells surrounding poromas which were positive for LS59 and NKI/C-3. The labeling with wide spectrum keratin antiserum was low compared to epidermal keratinocytes. Porocarcinomas made some difference. CEA-positive single vacuolated cells could be observed, and S100-positive cells failed to show dendrites as in poromas. Some tumor cell clusters were stained weakly with LS59 and NKI/C-3 in addition to surrounding cells in both tumor entities. Three out of eight porocarcino...Continue Reading

Citations

Nov 25, 2011·The American Journal of Dermatopathology·Mai P Hoang
May 1, 2009·Diagnostic Cytopathology·Limin YuXin Jing
Jun 8, 2001·The American Journal of Surgical Pathology·A RobsonE Calonje

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