PMID: 2510778Jan 1, 1989Paper

Immunohistochemistry of neuron-specific and glia-specific proteins

Archives of Histology and Cytology
T IwanagaT Fujita

Abstract

This paper reviews the immunohistochemical distribution of four brain-derived proteins, NSE, NFP, spot 35 and S-100 protein, in neuronal and paraneuronal tissues, concentrating on the results of our own research group. Neuron-specific enolase (NSE), a brain-specific isozyme of the glycolytic enzyme enolase, is characterized by its consistent occurrence in the cytoplasm of mature neurons. Immunoreactivity for NSE has been found in almost all paraneurons of both sensory and endocrine nature, suggesting that a unique system of intracellular energy metabolism may be shared by neurons and paraneurons. Neurofilament protein (NFP), a neuronal cytoskeletal protein, is immunohistochemically recognized in only a part of neurons, apparently due to the scarcity in neurofilaments in some neurons or to a decreased antigenicity for NFP in the cell. Similarly, only small populations of cells in restricted types of paraneurons, including gut endocrine cells and thyroid C cells, are immunoreactive for NFP. However, the potentiality for paraneurons to express NFP is given credence by the fact that its immunoreactivity is rather frequently found in the neoplasmas of paraneurons which normally do not show this immunoreactivity. Spot 35 protein whic...Continue Reading

Citations

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