Immunohistochemistry with a pan-TRK antibody distinguishes secretory carcinoma of the salivary gland from acinic cell carcinoma

Histopathology
Yin P HungJason L Hornick

Abstract

Secretory carcinoma (previously known as mammary analogue secretory carcinoma) is characterised by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histological overlap with other salivary gland tumours, secretory carcinoma can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK antibody shows promise for identifying tumours with NTRK fusions. The aim of this study was to evaluate the utility of pan-TRK immunohistochemistry in distinguishing secretory carcinoma from mimics. We examined whole-tissue sections from 86 tumours, including 14 secretory carcinomas (12 parotid primaries and one buccal primary, and one metastasis; five with ETV6 rearrangement confirmed by fluorescence in-situ hybridisation, and one with ETV6-NTRK3 fusion and one with ETV6-RET fusion detected by targeted sequencing), 14 acinic cell carcinomas, 18 polymorphous adenocarcinomas, 20 low-grade mucoepidermoid carcinomas, and 20 pleomorphic adenomas. Immunohistochemistry was performed with a pan-TRK rabbit monoclonal antibody. Pan-TRK staining was detected in nine (64%) secretory carcinomas, all with a nuclear pattern and four with diffuse staining (>50% of cells). Among other tumour types, pan-TRK immunoreactivity wa...Continue Reading

References

Feb 14, 1998·Nature Genetics·S R KnezevichP H Sorensen
Sep 5, 2002·The Journal of Pathology·Masanori HisaokaHiroshi Hashimoto
Jun 4, 2011·Virchows Archiv : an International Journal of Pathology·Christopher GriffithSimion I Chiosea
Feb 4, 2012·The American Journal of Surgical Pathology·Simion I ChioseaRaja R Seethala
Mar 31, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jacinthe ChênevertRaja R Seethala
Apr 6, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rie OhtomoHitoshi Tsuda
May 18, 2013·The American Journal of Surgical Pathology·Justin A BishopWilliam H Westra
Jun 29, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andre PintoCarmen Gomez-Fernandez
Sep 11, 2014·Nature Communications·Nicolas StranskyChristoph Lengauer
Jun 4, 2016·The American Journal of Surgical Pathology·Narasimhan P AgaramChristopher Dm Fletcher
Jun 11, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Snjezana DoganRonald A Ghossein
Jul 13, 2016·Head and Neck Pathology·Jennifer DettloffMarino E Leon
May 31, 2017·Histopathology·Elizabeth Y WuJustine A Barletta
Jul 19, 2017·The American Journal of Surgical Pathology·Jaclyn F HechtmanAchim A Jungbluth
Sep 12, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Alissa Kanaan
Oct 28, 2017·The American Journal of Surgical Pathology·Alena SkálováAlfio Ferlito
Nov 4, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alanna J ChurchMarian H Harris
Nov 7, 2017·Human Pathology·Tao HuangJeffrey L Myers
Feb 15, 2018·The American Journal of Surgical Pathology·Ilan WeinrebCristina R Antonescu
Feb 22, 2018·The New England Journal of Medicine·Alexander DrilonDavid M Hyman
Mar 20, 2018·The American Journal of Surgical Pathology·Sarah ChiangCristina R Antonescu
Apr 24, 2018·The American Journal of Surgical Pathology·Erin R RudzinskiJessica L Davis
Apr 28, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David L KolinBrooke E Howitt
Sep 2, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zoran GatalicaSemir Vranic

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Citations

Jan 26, 2020·International Journal of Molecular Sciences·Alessandro GambellaLuca Bertero
Aug 20, 2019·Virchows Archiv : an International Journal of Pathology·Diana BellAdel K El-Naggar
Dec 4, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Angela ChouAnthony J Gill
Mar 25, 2020·Advances in Anatomic Pathology·Andrew M Bellizzi
Sep 11, 2020·Head and Neck Pathology·Kristine S WongVickie Y Jo
Mar 19, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Briac GuibourgArnaud Uguen
Jan 17, 2021·Medical Molecular Morphology·Hiroshi HaradaAkira Kurose
Sep 10, 2019·The American Journal of Surgical Pathology·Beth T HarrisonStuart J Schnitt
Nov 17, 2020·Frontiers in Oncology·Larissa Di VilleneuveGustavo Schvartsman
Jan 7, 2021·Advances in Anatomic Pathology·M Hasan Toper, Sulen Sarioglu
Apr 14, 2021·Annales de pathologie·Arnaud UguenJulien Adam
May 26, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Yonca KanberManon Auger
Jan 23, 2021·The American Journal of Surgical Pathology·Masato NakaguroToshitaka Nagao
Jun 28, 2021·Genes, Chromosomes & Cancer·Justin BubolaBrendan C Dickson
Oct 29, 2020·Archives of Pathology & Laboratory Medicine·Esther CondeFernando Lopez-Rios
Jun 5, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Lísia Daltro Borges AlvesDaniel Cohen Goldemberg
Apr 27, 2021·The American Journal of Surgical Pathology·Marie Csanyi-BastienMarick Laé

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