PMID: 7033146Aug 15, 1981Paper

Immunohistologic evidence for the role of antibody and macrophages in regression of the murine T1699 mammary adenocarcinoma

International Journal of Cancer. Journal International Du Cancer
M Key, J S Haskill

Abstract

The regression or progression of the T1699 murine mammary adenocarcinoma was analyzed with histologic an immunohistologic techniques to determine the tissue distribution of both macrophages and anti-tumor antibody. Changes in integrity of tumor blood vessels were apparent during tumor growth and regression. Tumors at early stages of growth were invaded in the capsule by multiple vascular branches which later permeated tha tumor. Following the appearance of anti-tumor in the serum, these vessels often showed immune complex deposition which preceded vessel leakage, destruction and hemorrhage. After these changes, tumor cells appeared coated with antibody. Macrophages appeared predominantly in the tumor capsule during early stages of tumor growth, while at later stage they were observed within tumors most prominently near the edge of growing hemorrhagic and necrotic areas. As tumors regressed, connective tissue septation lined by macrophages became apparent. Phagocytosis of seemingly intact tumor cells was common and appeared to account for much of the loss in tumor cell numbers. In immunosuppressed animals (ATXBM,450R) in which tumor progression always occurred, the above features were markedly diminished or absent. This model em...Continue Reading

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Citations

Oct 31, 2002·Immunology and Cell Biology·Scott N Byrne, Gary M Halliday
Jan 2, 1992·International Journal of Cancer. Journal International Du Cancer·J Vaage
Jan 21, 1992·International Journal of Cancer. Journal International Du Cancer·H M BlottièreJ Le Pendu

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