PMID: 19867210May 1, 1962Paper

IMMUNOHISTOLOGIC STUDIES ON ANTIGEN-ANTIBODY REACTIONS IN THE AVASCULAR CORNEA : I. REACTIONS IN RABBITS ACTIVELY SENSITIZED TO FOREIGN PROTEIN

The Journal of Experimental Medicine
F G GERMUTHA D Pollack

Abstract

The injection of antigen into the center of the avascular cornea of homologously sensitized animals induced a ring of opacification between the center of the cornea and the limbus. This ring of opacification was composed of a line of deeply eosinophilic amorphous material in a matrix of swollen collagen fibers, palisaded by polymorphonuclear leucocytes. By use of fluor-tagged antigen, it was shown that the line of damage in the cornea coincided with the precipitation of antigen presumably by antibody entering the cornea from the limbal vessels. With the passage of time, the antigen-antibody precipitates were removed, at least in part by phagocytosis, and the ring of opacification was replaced by ingrowing blood vessels surrounded by plasma cells. Treatment of sensitized animals with nitrogen mustard showed that antigen-antibody interaction could injure the corneal stroma in the relative absence of polymorphonuclear leucocytes.

Citations

Jul 1, 1965·The Journal of Pathology and Bacteriology·J B Blackwell
Jan 1, 1986·Documenta Ophthalmologica. Advances in Ophthalmology·L D Ormerod
Feb 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·R OsuskyP G Lerch
Nov 14, 1997·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T DammsG K Klintworth
Jan 1, 1967·Archiv für die gesamte Virusforschung·L H Collier
Nov 25, 1981·Documenta Ophthalmologica. Advances in Ophthalmology·N W Dekkers
Nov 1, 1985·Veterinary Immunology and Immunopathology·A E ParmaR A Bowden
Jul 16, 2003·Eye & Contact Lens·Marc W RobboyCarolyn M Kalsow
Mar 1, 1982·American Journal of Ophthalmology·J B BelmontD Dulay
Sep 1, 1979·American Journal of Ophthalmology·A M Silverstein
Sep 1, 1979·American Journal of Ophthalmology
Aug 1, 1965·American Journal of Ophthalmology·F M POLACK
Sep 1, 1991·Cellular Immunology·A M Silverstein
Nov 1, 1984·The British Journal of Ophthalmology·R D Young, P G Watson
Nov 1, 1984·The British Journal of Ophthalmology·N H WelshS L Gaffin

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