PMID: 7014391Mar 1, 1981Paper

Immunohistological characterisation of intraepithelial lymphocytes of the human gastrointestinal tract

Gut
W S SelbyD P Jewell

Abstract

Intraepithelial lymphocytes (IEL) of the normal human stomach, small intestine, and large intestine have been characterised in tissue sections by a double marker immunofluorescent technique. A panel of reagents was used in combination, including antisera to T lymphocyte antigen (HuTLA), Ia-like (p28, 33) antigens and immunoglobulin subclasses, as well as a mouse monoclonal antibody to a human leucocyte antigen (HLe-1). In stomach and proximal small intestine over 95% of IEL were T lymphocytes (HLe-1+, HuTLA+). The proportion was slightly lower in the colon and rectum (85--95%). IEL rarely expressed Ia-like antigens. B lymphocytes were not seen within the epithelium of any of the tissues examined. The functions of IEL must be assessed in the light of the finding that they are predominantly T cells.

References

Jan 1, 1979·Scandinavian Journal of Immunology·P NiaudetD Horwitz
Nov 1, 1978·The Journal of Experimental Medicine·R L EvansS F Schlossman
Mar 1, 1979·European Journal of Immunology·A J McMichaelC Milstein
Jun 1, 1974·European Journal of Immunology·D Guy-GrandP Vassalli
Feb 1, 1971·Journal of Ultrastructure Research·P G Toner, A Ferguson
Dec 1, 1969·Journal of Ultrastructure Research·C J Pfeiffer, J Weibel
May 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·K E FichteliusR A Good
Jan 1, 1980·The Journal of Experimental Medicine·D T YuH G Kunkel

❮ Previous
Next ❯

Citations

Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·P MöllerM Hüpen
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·K GeboesV Desmet
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·M VecchiR de Franchis
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y TsutsumiK Watanabe
Sep 1, 1988·Diseases of the Colon and Rectum·T MatsumotoK Kobayashi
Jan 1, 1991·Immunologic Research·T S Halstensen, P Brandtzaeg
Jun 20, 2007·International Journal of Colorectal Disease·Amosy E M'KomaAlan J Herline
Oct 1, 1985·Veterinary Immunology and Immunopathology·N Craven, M R Williams
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J L Díaz-JuárezJ C Prieto
Jul 1, 1987·Baillière's Clinical Gastroenterology·M D Kaye
Jul 1, 1987·Baillière's Clinical Gastroenterology·P D Howdle, M S Losowsky
Feb 13, 2001·Developmental and Comparative Immunology·G I Solano-AguilarJ K Lunney
Oct 16, 2002·Developmental and Comparative Immunology·J M Old, E M Deane
Feb 1, 1997·Immunology Letters·J A Kearsey, A W Stadnyk
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H BleibergP Stryckmans
Aug 10, 2000·The British Journal of Surgery·M CaplinA Dhillon
Apr 8, 1982·The New England Journal of Medicine·J B Kirsner, R G Shorter
Jul 1, 1996·The American Journal of Surgical Pathology·N AlsaighA Leichtner
Aug 10, 2000·The American Journal of Surgical Pathology·S B ClarkJ R Goldblum
Nov 1, 2002·The American Journal of Surgical Pathology·Heidi SappRobert D Odze
Apr 17, 2013·Biochemistry. Biokhimii︠a︡·T S Zamolodchikova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.