PMID: 15332601Aug 31, 2004Paper

Immunohistological identification of receptor activator of NF-kappaB ligand (RANKL) in human, ovine and bovine bone tissues

Journal of Materials Science. Materials in Medicine
R J Mueller, R G Richards

Abstract

Receptor activator of NF-kappaB ligand (RANKL, also called ODF/TRANCE/OPGL) is the final factor of osteoclast differentiation. Osteoclastogenesis may be determined by its receptor RANK and the relative ratio of RANKL to its decoy receptor osteoprotegerin (OPG), and alterations in this ratio may be a major cause of bone loss in many metabolic and immunologic disorders. In order to get a better insight into this complex regulatory system, this study aimed to determine where RANKL protein is located in bone tissues. RANKL was stained immunohistochemically in ex vivo human, ovine and bovine bone tissue. RANKL was observed labelled in the membrane of osteoblasts, osteocytes and osteoclasts and their surrounding matrix. In cartilage, which was used as a negative tissue control, chondrocytes were not stained. The presence of RANKL protein in the membrane of osteoblasts and also the secretion of RANKL by osteoclasts has been hypothesised in earlier studies. In this study, RANKL protein was shown histologically for the first time in the membrane and in the long processes of osteocytes. The result strongly suggests the crucial involvement of osteocytes in terms of orchestrating bone remodelling by influencing differentiation and activati...Continue Reading

Citations

Aug 19, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D M Findlay, G J Atkins
Mar 20, 2012·Current Osteoporosis Reports·Natalie A Sims, Nicole C Walsh
Jan 15, 2014·BoneKEy Reports·Ron Shahar, Mason N Dean
Apr 17, 2016·Biointerphases·Luisa Mayorga SzottBuddy D Ratner
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiyu LiuDa Jing

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