PMID: 9438472Jan 23, 1998Paper

Immunohistological studies on macrophages in lymph nodes of onchocerciasis patients after treatment with ivermectin

Tropical Medicine & International Health : TM & IH
J KnabD W Büttner

Abstract

The role of macrophages in the killing and elimination of microfilariae (mf) was studied immunohistologically in 14 lymph nodes from 10 patients with generalized onchocerciasis 20-68 h after treatment with a single oral dose of 150 microg/kg ivermectin. Mf with signs of damage at light microscopical level were surrounded by a cellular infiltrate comprising macrophages, eosinophils and neutrophils, whereas light microscopically intact mf mostly showed no cellular reaction. Resident mature macrophages expressing the CD 68 epitope usually neither migrated nor attached to damaged mf, especially on the first and second day after ivermectin treatment. However, many young invading macrophages labelled for the L1 protein (antibodies 27 E 10, MAC 387, S 36.48 and 8.5C2) were found within the cellular infiltrate around damaged mf and in adherence to the mf in all lymph nodes after ivermectin treatment. Free L1 protein was observed on the cuticle of the mf. The attacking macrophages contained increased amounts of the enzymes lysozyme, alpha-1-antichymotrypsin and alpha-1-antitrypsin compared to resident macrophages. Free enzymes were found on the cuticle of the mf and around them, indicating a role of these enzymes in the inflammatory rea...Continue Reading

Citations

Jul 25, 2009·Parasitology Research·Klaus D Erttmann, Dietrich W Büttner
May 13, 2008·The Lancet Infectious Diseases·María-Gloria BasáñezMichel Boussinesq
Mar 21, 2007·Research in Veterinary Science·M K BörküA Atasever
May 4, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P J CooperT B Nutman
Dec 17, 1998·Tropical Medicine & International Health : TM & IH·G WildenburgD W Büttner
Jul 28, 2020·Expert Review of Anti-infective Therapy·Philip MiltonMaría-Gloria Basáñez

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