Immunohistological study of the depressed cutaneous DTH response in sheep naturally infected with an ovine lentivirus (Maedi-Visna virus)

Clinical and Experimental Immunology
I T Pyrah, N J Watt

Abstract

The gross and immunohistological characteristics of the purified protein derivative (PPD)-induced cutaneous DTH reaction were studied in a group of sheep naturally infected with Maedi-Visna virus (MVV), and compared with reactions obtained in a matched control group. There was a marked, but variable, depression in the DTH lesion in the MVV group associated with a decreased density of polymorphonuclear neutrophils (PMN) and CD4+ cells in the early reaction. There were no significant differences in the densities of CD8+, gamma/delta T cells, macrophages, B cells and MHC class H-expressing cells. This work indicates that there is a significant alteration in the initial trafficking of PMN and CD4+ cells into a DTH response area in sheep infected with MVV.

Citations

Oct 12, 2000·Journal of Virology·S RyanB Blacklaws
Sep 28, 2013·Veterinary Research·Helena CrespoRamsés Reina
Aug 7, 2013·Viruses·Ramsés ReinaBeatriz Amorena
Aug 26, 2014·Viruses·Nancy StonosNiel Karrow
Dec 3, 2010·Veterinary Immunology and Immunopathology·Ramses ReinaSergio Rosati
Jan 25, 2000·The Journal of General Virology·R A JusteA de La Concha-Bermejillo

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