Immunohistological study on collagenous proteins of benign and malignant human cartilaginous tumours of bone

Virchows Archiv. A, Pathological Anatomy and Histopathology
Y UedaI Nakanishi

Abstract

The immunohistological distribution of collagen types I, II, III, V and VI in human benign and malignant cartilaginous tumours of bone was examined with regard to their aggressiveness. The matrix of enchondromas consisted of type II collagen distributed diffusely, and type VI predominantly localized in the immediate surroundings of the cells. Types I, III and V collagen were not found. These findings were similar to the distribution of collagenous proteins in normal hyaline cartilage where each lobule was consistently rimmed by types I and V collagen. In grade 1 chondrosarcomas, the main collagenous components of matrix were also types II and VI collagen. Type II was sometimes found in the cytoplasm of tumour cells and type VI tended to lose territorial localization. In addition, type I collagen was demonstrated consistently and type V in some cases. In grade 2 chondrosarcomas, type II collagen was demonstrated not only in the matrix but occasionally in the cytoplasm of tumour cells. Type VI was dispersed in the intercellular areas. The other collagenous proteins such as types I, III and V were also present in the matrix. In grade 3 chondrosarcomas, type II collagen was localized predominantly in the cytoplasm of tumour cells a...Continue Reading

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Citations

Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·T KunisadaM Namba
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·H TsuchiyaK Tomita
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·G EdelP Wuisman
Feb 26, 2005·Virchows Archiv : an International Journal of Pathology·Thomas KalinskiAlbert Roessner
Nov 26, 2003·Biochemical Pharmacology·Li ShaoLawrence Weissbach
Aug 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S P ScullyJ M Harrelson
Mar 1, 1997·Human Pathology·C PovýsilZ Matejovský
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xiaoling JiangSean P Scully
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jin Woo LeeSean P Scully
Oct 23, 2004·Journal of Cellular Physiology·Xiaoling JiangSean P Scully
Nov 20, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H ChanskyL J Sandell
Apr 13, 2000·International Journal of Cancer. Journal International Du Cancer·B Trueb, B F Odermatt

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