Immunohistology and remodeling in fatal pediatric and adolescent asthma

Respiratory Research
Kristiina MalmströmMika J Mäkelä

Abstract

Thickening of reticular basement membrane, increased airway smooth muscle mass and eosinophilic inflammation are found in adult fatal asthma. At the present study the histopathology of fatal paediatric and adolescent asthma is evaluated. Post-mortem lung autopsies from 12 fatal asthma cases and 8 non-asthmatic control subjects were examined. Thickness of reticular basement membrane (RBM) and percentage of airway smooth muscle (ASM%) mass area were measured and inflammatory cells were counted. Patient records were reviewed for clinical history. The age range of the cases was from 0.9 to 19.5 years, eight were males and five had received inhaled corticosteroids. Thickened RBM was detected in majority of the cases without any correlation to treatment delay, age at onset of symptoms or diagnosis. In the large airways ASM was clearly increased in one third of the cases whereas the median ASM% did not differ from that in healthy controls (14.0% vs. 14.0%). In small airways no increase of ASM was found, instead mucous plugs were seen in fatal asthma. The number of eosinophils, plasmacytoid dendritic cells, macrophages, and B-cells were significantly increased in fatal asthma cases compared with controls and the two latter correlated w...Continue Reading

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Citations

Sep 6, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Ibon Eguíluz-GraciaFrode L Jahnsen
Jan 11, 2020·American Journal of Respiratory Cell and Molecular Biology·Andrew T ReidDarryl A Knight
Mar 12, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Kristiina MalmströmMika J Mäkelä
Oct 28, 2017·Current Opinion in Pulmonary Medicine·Louis-Philippe Boulet
Feb 23, 2018·Pediatric Pulmonology·Jose A Castro-RodriguezAndrew Bush
Jan 22, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Wytse B van den BoschHarm A W M Tiddens
Oct 23, 2021·The Clinical Respiratory Journal·Maria WawszczakJoanna Peradzyńska

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