Immunoinformatics design of multiepitopes peptide-based universal cancer vaccine using matrix metalloproteinase-9 protein as a target.

Immunological Medicine
A. H. AbdelmoneimA. M. Makhawi

Abstract

A new approach toward cancer therapy is the use of cancer vaccine, yet the different molecular bases of cancers, reduce the effectiveness of this approach. In this article, we aim to use matrix metalloproteinase-9 protein (MMP9) which is an essential molecule in the survival and metastasis of all types of cancers as a target for universal cancer vaccine design. The reference sequence of MMP9 protein was obtained from NCBI databases. Furthermore, the B-cell and T cell-related peptides were analyzed using the IEDB website and other related soft wares. The best candidate peptides were then visualized using chimera software. Three peptides were found to be good candidates for interactions with B cells (SLPE, RLYT, and PALPR), while 10 peptides were found as good targets for interactions with MHC1 and another 10 peptides founded suitable for interactions with MHC2 with population coverages of 94.77 and 90.67%, respectively. Finally, the immune response simulation and molecular docking were done using the C-IMMSIM simulator and AutoDock Vina to confirm the effectiveness of the proposed vaccine. By the end of this project: twenty-three peptide-based vaccine was designed for use as a universal cancer vaccine which has a high world popu...Continue Reading

References

Dec 10, 1990·FEBS Letters·A S Kolaskar, P C Tongaonkar
Apr 30, 2003·Protein Science : a Publication of the Protein Society·Morten NielsenOle Lund
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian PelteFlorian Kern
Jul 21, 2004·Journal of Computational Chemistry·Eric F PettersenThomas E Ferrin
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ettore BiagiMalcolm Brenner
Mar 21, 2006·BMC Bioinformatics·Huynh-Hoa BuiAlessandro Sette
Apr 26, 2006·Immunome Research·Jens Erik Pontoppidan LarsenMorten Nielsen
Jan 9, 2007·BMC Bioinformatics·Irini A Doytchinova, Darren R Flower
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey SchlomJames L Gulley
Apr 29, 2009·Journal of Computational Chemistry·Garrett M MorrisArthur J Olson
Oct 12, 2010·Bioinformatics·Christophe N MagnanPierre Baldi
Nov 26, 2010·BMC Bioinformatics·Peng WangBjoern Peters
Mar 26, 2011·Biomolecular Concepts·Scott A Hollingsworth, P Andrew Karplus
Apr 8, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin A Cheever, Celestia S Higano
May 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yu SawadaTetsuya Nakatsura
May 23, 2012·Nucleic Acids Research·Yohan KimBjoern Peters
Jan 1, 2011·Experimental and Therapeutic Medicine·Kiyotaka OkunoKazuki Ueda
Oct 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Magalie DossetOlivier Adotévi
Dec 7, 2013·Biology Direct·Sandeep Kumar DhandaGajendra P S Raghava
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 16, 2014·Clinical and Experimental Vaccine Research·Eun Hee Chung
Jun 1, 2014·Journal of Molecular Modeling·Ivan DimitrovIrini Doytchinova
Jul 9, 2014·Clinical and Experimental Vaccine Research·Md Selim Ahmed, Yong-Soo Bae
Feb 26, 2015·Human Vaccines & Immunotherapeutics·Petr G Lokhov, Elena E Balashova
Jan 1, 2014·Vaccines·Weidang LiAshlesh K Murthy
Sep 17, 2015·Scandinavian Journal of Primary Health Care·Benedicte Iversen Scheel, Knut Holtedahl
Apr 27, 2016·Nucleic Acids Research·Sheng WangJinbo Xu
Jun 14, 2016·Human Vaccines & Immunotherapeutics·R Servín-BlancoK Manoutcharian
Jul 20, 2016·Disease Markers·Katarzyna JakubowskaKatarzyna Guzińska-Ustymowicz
Jul 28, 2016·International Journal of Molecular Sciences·Akinori Tokito, Michihisa Jougasaki
Feb 12, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·J Sybil BiermannJillian L Scavone
Apr 30, 2017·Journal of Thoracic Disease·Hiroki Nagai, Young Hak Kim
May 2, 2017·Frontiers in Oncology·Jeff KamtaSihem Ait-Oudhia
May 5, 2017·Nucleic Acids Research·Martin Closter JespersenPaolo Marcatili
Jun 3, 2017·The Indian Journal of Medical Research·Raveendran K Pillai, K Jayasree
Aug 9, 2017·JAMA : the Journal of the American Medical Association·Rebecca L SiegelAhmedin Jemal
Mar 11, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·William J GradisharDorothy A Shead

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Nov 18, 2020·Journal of Molecular Liquids·Sajjad AhmadMuzammil Hasan Najmi
Feb 19, 2021·Journal of Biomolecular Structure & Dynamics·Elham MahdevarVahid Iranpur Mobarakeh
Aug 30, 2021·Trends in Pharmacological Sciences·Shruthi Polla RaviArghya Paul

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