Immunoliposomal delivery of 213Bi for alpha-emitter targeting of metastatic breast cancer.

Cancer Research
Mohanambe LingappaG Sgouros

Abstract

Current treatment for late-stage metastatic breast cancer is largely palliative. alpha-Particles are highly potent, short-range radiation emissions capable of sterilizing individual cells with one to three traversals of the cell nucleus. The alpha-emitter, (213)Bi (T(1/2) = 45.6 min), was conjugated to a 100-nm diameter liposomal-CHX-A''-DTPA construct, upon which the rat HER2/neu reactive antibody, 7.16.4, was grafted. A conjugation time of 10 minutes was achieved giving a specific activity corresponding to 0.1 (213)Bi atom per liposome; stability in vitro and in vivo was confirmed. Efficacy in a rat/neu transgenic mouse model of metastatic mammary carcinoma was investigated. Three days after left cardiac ventricular injection of 10(5) rat HER-2/neu-expressing syngeneic tumor cells, macrophage-depleted Neu-N mice were treated by i.v. injection with (a) 19.2 MBq (520 muCi) of liposome-CHX-A''-DTPA-(213)Bi, (b) 19.2 MBq of liposome-CHX-A''-DTPA-(213)Bi-7.16.4, (c) 4.44 MBq (120 muCi) of (213)Bi-7.16.4, and (d) cold (nonradioactive) liposome-CHX-A''-DTPA-7.16.4 as control. Treatment with (a) increased median survival time to 34 days compared with 29 days for the untreated controls (P = 0.013) and 27 days for treated cold controls...Continue Reading

References

Apr 24, 1999·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·M R McDevittD A Scheinberg
Oct 21, 1999·International Journal of Pharmaceutics·J D Castile, K M Taylor
Feb 1, 1960·Health Physics·P W DURBIN
Mar 20, 2004·Science·Theresa M Allen, Pieter R Cullis
Jul 23, 2004·Expert Opinion on Therapeutic Targets·Charles O NobleDaryl C Drummond
Jan 25, 2005·Cancer Biotherapy & Radiopharmaceuticals·Shota KonishiStanley Goldsmith
Oct 1, 2005·Analytical Chemistry·C ApostolidisA Morgenstern
Dec 16, 2006·Current Pharmaceutical Design·Amitava MitraHamidreza Ghandehari
Oct 16, 2007·Bioconjugate Chemistry·Stavroula SofouGeorge Sgouros
Feb 6, 2008·Expert Opinion on Drug Delivery·Stavroula Sofou, George Sgouros
Feb 27, 2008·Cancer Biotherapy & Radiopharmaceuticals·George Sgouros, Hong Song
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hong SongGeorge Sgouros
Jan 19, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·George SgourosPat B Zanzonico

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Citations

Dec 7, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Young-Seung Kim, Martin W Brechbiel
May 13, 2014·Immunotherapy·Christof Seidl
Jun 29, 2016·Expert Opinion on Drug Delivery·Tessa van der GeestOtto C Boerman
Jan 29, 2018·Annals of Nuclear Medicine·Geetanjali Arora, Gurupad Bandopadhyaya
Mar 22, 2018·International Journal of Molecular Sciences·Benjamin B KastenDonald J Buchsbaum
Jan 19, 2018·Annual Review of Biomedical Engineering·Michael R McDevittStavroula Sofou
Mar 24, 2020·Cancer Biotherapy & Radiopharmaceuticals·Hossein Jadvar
Oct 4, 2017·Current Medicinal Chemistry·Mateusz KowalikBarbara Barszcz
Jun 21, 2020·Chemistry and Physics of Lipids·Liliana Aranda-LaraKeila Isaac-Olivé
May 1, 2021·Pharmaceutics·Stephen AhenkorahFrederik Cleeren

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