Immunolocalization of acidic and basic fibroblast growth factors in porcine uterine and conceptus tissues

Biology of Reproduction
A GuptaL A Jaeger

Abstract

Immunohistochemical techniques were used to localize acidic and basic fibroblast growth factor (FGF) polypeptides in porcine uterine and conceptus tissues collected on Days 10 through 14 of gestation, which is the peri-implantation period, and in uterine tissues collected on the same days of the estrous cycle. Our results demonstrate differential expression of acidic and basic FGF (aFGF, bFGF) in porcine uterine and conceptus tissues. Localization of these peptides in the uterus of cycling and pregnant pigs was different from that reported for other species, suggesting species-specific roles for FGFs in early pregnancy. Increases in both cytoplasmic and nuclear bFGF immunostaining were detected in uterine luminal and glandular epithelial cells from Days 10 to 14 of gestation but not in the uterine epithelium of cycling pigs. Acidic FGF immunostaining was not detected in luminal or glandular epithelium of either cycling or pregnant uterine tissue; however, differential stromal staining was observed. Uterine tissues collected from pigs on Days 10-14 of the estrous cycle had diffuse aFGF immunostaining throughout the stroma. During early pregnancy, however, intense aFGF immunostaining was concentrated around the glandular epitheli...Continue Reading

Citations

Sep 1, 2012·Reproduction, Fertility, and Development·Roberta Nogueira ChavesJosé Ricardo de Figueiredo
Feb 21, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·L A OkumuP Lonergan
Feb 27, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kundendu Arya BishenKapaettu Satyamoorthy
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Dec 15, 2005·Journal of Cell Science·Leanne CottonMoira K O'Bryan
Jul 4, 2021·Scientific Reports·Ewelina Goryszewska-SzczurekAgnieszka Waclawik

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