PMID: 8602333Aug 1, 1995Paper

Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure

Oral Microbiology and Immunology
N Tani-IshiiP Stashenko

Abstract

The bone-resorptive cytokines interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of many chronic inflammatory diseases, including pulpitis and apical periodontitis.To further elucidate their role in these disorders, we have identified cells that express IL-1 alpha and TNF alpha in infected pulps and in developing rat periapical lesions after surgical pulp exposure. As detected by immunohistochemistry, IL-1 alpha- and TNF alpha-positive cells were present as early as 2 days after pulp exposure in both the pulp and periapical region. The numbers of cytokine-expressing cells increased up to day 4 in the pulp and up to day 30 in the periapex. In contrast, cells expressing IL-1 beta and TNF beta, the homologous forms of these mediators, were not found in pulp or periapical lesions during this period. Cells expressing IL-1 alpha and TNF alpha were identified primarily as macrophages and fibroblasts, with occasional staining of polymorphonuclear leukocytes. Osteoblasts and osteoclasts were also positive, whereas lymphocytes were negative. In general, cytokine-expressing cells were located proximal to abscesses and the root apex. These findings demonstrate that cells that express bone-resorpti...Continue Reading

References

Mar 1, 1992·Oral Surgery, Oral Medicine, and Oral Pathology·R A BarkhordarC Hayashi
Aug 1, 1991·Journal of Periodontology·P StashenkoS S Socransky
Oct 1, 1991·Journal of Dental Research·C Y Wang, P Stashenko
Jun 1, 1990·Endodontics & Dental Traumatology·P Stashenko
Jan 1, 1989·Immunological Investigations·P StashenkoF E Dewhirst
Nov 1, 1987·Journal of Endodontics·S M Yu, P Stashenko
May 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y BandoM Harris
Mar 1, 1993·Journal of Endodontics·C Y Wang, P Stashenko
Sep 1, 1965·Oral Surgery, Oral Medicine, and Oral Pathology·S KAKEHASHIR J FITZGERALD

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Citations

Dec 3, 2002·Archives of Medical Research·Sonja Pezelj-RibaricMarica Simunovic-Soskic
Jan 12, 2001·Oral Microbiology and Immunology·I J Márton, C Kiss
Apr 1, 1997·Oral Microbiology and Immunology·C Y WangP Stashenko
Feb 13, 2001·Infection and Immunity·K BaltoP Stashenko
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sze-Kwan LinChi-Yuan Hong
May 7, 2011·Journal of Oral Microbiology·Dana T GravesGustavo P Garlet
Feb 8, 2002·Acta Odontologica Scandinavica·E BerggreenK J Heyeraas
Jun 29, 2010·Journal of Dentistry·Paul R CooperAnthony J Smith
Nov 11, 2008·Archives of Oral Biology·J L BainR B Johnson
Oct 22, 2008·Journal of Endodontics·Asma A KhanKenneth M Hargreaves
May 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Dragan GazivodaMiodrag Colic
May 27, 2009·International Endodontic Journal·F-M HuangY-C Chang
Mar 21, 2008·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Maja KovacevićMiljenko Kovacević
Oct 7, 2011·Journal of Cellular Biochemistry·Xuechao YangMingwen Fan
Feb 8, 2014·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Kathleen G NeivaRoberta Pileggi
Nov 20, 2013·International Endodontic Journal·M YadlapatiR M Silva
Mar 13, 1999·Archives of Oral Biology·N Kawashima, P Stashenko
Nov 6, 2015·Mediators of Inflammation·Jean-Christophe FargesPaul R Cooper

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