PMID: 7513314May 1, 1994Paper

Immunolocalization of granulocyte-colony-stimulating factor in human glial and primitive neuroectodermal tumors

International Journal of Cancer. Journal International Du Cancer
A C StanT Pietsch

Abstract

Granulocyte-colony-stimulating factor (G-CSF) is a hematopoietic cytokine that regulates the differentiation of myeloid progenitors and the function of mature neutrophils. It is produced in vitro by monocytes/macrophages, mesothelial cells, fibroblasts and endothelial cells after appropriate induction by inflammatory mediators like IL-1 and TNF. Normal as well as tumorous glial cells can also be induced to produce CSFs in vitro. However, little is yet known about the in vivo expression of G-CSF as a mediator in inflammation and malignancy within the human central nervous system. The aim of the present study was to investigate by immunostaining the expression of the G-CSF protein within non-tumorous and tumorous glial tissues, and primitive neuroectodermal tumors. Using the murine monoclonal anti-G-CSF TM 82/60 antibody, we found high G-CSF expression in astrocytoma WHO grades I and II and reactive brain tissue, low expression in astrocytoma WHO grade III, and none in glioblastoma, oligodendroglioma WHO grades II and III, and medulloblastoma. In consecutive sections of the tissue samples, G-CSF protein was localized in GFAP-positive glial cells, but not in macrophages/microglial cells, which expressed HLA-DR, detected by the ant...Continue Reading

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Citations

Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M M ValterT Pietsch
Mar 21, 1998·Pathology International·H UsudaT Iizumi
Apr 17, 2002·Expert Opinion on Biological Therapy·Bela Bodey
Mar 27, 2010·Immunology Letters·Anirban Ghosh, Swapna Chaudhuri
Oct 16, 2002·Glia·Manuel B GraeberGeorg W Kreutzberg
Nov 26, 2008·Journal of Leukocyte Biology·Bart R TambuyzerEtienne J Nouwen
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Flora ZavalaJean-François Bach
Mar 29, 2014·International Journal of Immunopathology and Pharmacology·S NakayamaT Hanafusa

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