Immunolocalization of interstitial collagenase (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in radicular cysts

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
S K LinM Y Kuo

Abstract

To investigate the mechanisms involved in expansion of radicular cysts, monoclonal antibodies against interstitial collagenase (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1) were used to localize the sites of MMP-1 and TIMP-1 expression in 30 radicular cysts. Positive MMP-1 staining was detected in the lining epithelium and subepithelial fibroblasts, macrophages, endothelial cells and osteoblasts/osteocytes in all specimens. Positive TIMP-1 staining was identified in osteoblasts/osteocytes and endothelial cells of all specimens, and in the lining epithelium and subepithelial fibrous connective tissue wall of five radicular cysts with an intense inflammatory cell infiltrate. The number and distribution of positive cells for MMP-1 or TIMP-1 varied widely among individual specimens, but strong immunostaining was constantly detected at sites with prominent subepithelial inflammation. Results here support the hypothesis that MMP-1 may play an important role in the expansion of radicular cysts. The absence of TIMP-1 expression in lining epithelium and subepithelial fibroblasts and macrophages in most cases studied indicated that an imbalance between MMP-1 and TIMP-1 production may lead to radicular cyst expansion.

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Citations

Jul 18, 2002·European Journal of Oral Sciences·Sze-Kwan LinChi-Yuan Hong
Sep 2, 2009·Journal of Endodontics·Francisco Wanderley Garcia de Paula-SilvaYvonne Lorraine Kapila
Jun 6, 2009·Archives of Oral Biology·Mauro V CorottiJosé M Granjeiro
Oct 30, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Shin JungSam-Suk Kang
Nov 26, 2015·Journal of Endodontics·Lisiane BernardiPantelis Varvaki Rados
Nov 26, 2015·Journal of Oral Biology and Craniofacial Research·Atul Jain, Rachana Bahuguna
May 7, 2005·International Endodontic Journal·R LeonardiC Loreto
Aug 22, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Naida HadziabdicLjubomir Todorovic
Jul 1, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·G BhallaG V Sowmya
Apr 25, 2006·Journal of Endodontics·Ivan MoldauerSergio Kuttler
Sep 22, 2017·European Journal of Dentistry·Frederico Canato MartinhoGustavo Giacomelli Nascimento
Jan 19, 2021·Journal of Oral and Maxillofacial Pathology : JOMFP·V P AnshidaAnoop Samuel

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