Immunolocalization of metabotropic glutamate receptors 1 and 5 in the synaptic layers of the chicken retina

Visual Neuroscience
Madhumita Sen, Evanna Gleason

Abstract

We have examined the distribution of metabotropic glutamate receptors (mGluRs) 1 and 5 in the adult chicken retina using preembedding immuno-electronmicroscopy. Immunoreactivity for mGluRs 1 and 5 was found in both the outer plexiform layer (OPL) and the inner plexiform layer (IPL). For mGluR1, OPL labeling was observed at cone pedicles and horizontal and bipolar cell processes. In the IPL, mGluR1 labeling could be found on bipolar cell terminals, as well as postsynaptic processes, including amacrine cell processes. Neither presynaptic nor postsynaptic elements were labeled at rod synapses. For mGluR5, OPL labeling was associated with cone pedicles as well as bipolar and horizontal cell processes. As for mGluR1, rod synapses were unlabeled. In the IPL, labeling for mGluR5 was found on bipolar cell terminals and amacrine cell processes. The presynaptic expression of these receptors in the OPL was confirmed at the light level by double-labeling experiments with SV2. The distributions of mGluRs 1 and 5 indicate that they have the potential to regulate function in both synaptic layers. Furthermore, the similar expression patterns for these two receptors indicate that they might be co-expressed and thus have the potential to interac...Continue Reading

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Citations

May 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dona K Murphey, John H R Maunsell
Jan 18, 2012·The Journal of General Physiology·Ferenc I Hárosi, Iñigo Novales Flamarique
Apr 1, 2008·Cerebral Cortex·Bashir AhmedPer E Roland
Jan 1, 2016·Experimental Eye Research·E M Guimarães-SouzaK C Calaza
Sep 5, 2013·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Anuradha Dhingra, Noga Vardi
Dec 22, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Catherine A OpereNajam A Sharif
Nov 5, 2008·The Journal of Cell Biology·Sheila A BakerVadim Y Arshavsky
Dec 25, 2015·Neurochemical Research·Maria Rosaria RomanoFerdinando Nicoletti
May 27, 2020·Bioscience Reports·Ping-Ping ZhangLie-Cheng Wang

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