Immunolocalization of prealbumin as a marker for carcinoid tumours

The Journal of Pathology
I D MillerC H Horne


Using a PAP immunoperoxidase technique, we have demonstrated the plasma protein prealbumin in 92 (87 per cent) out of a series of 106 carcinoid tumours from various sites. The frequency of detection was greater than with the conventional stains; 83 (78 per cent) of the cases were positive for one or more of these stains. The Grimelius technique was by far the most effective of the conventional stains; it was positive in 81 (76 per cent) cases. We were unable to detect prealbumin in a variety of carcinomas. Although prealbumin identification did not appear to have any advantage over the routine stains in midgut-derived carcinoids, it was much more effective in the diagnosis of bronchial (foregut) and rectal (hindgut) carcinoids. We believe that prealbumin staining offers a cheap, reliable and valuable method for the detection of carcinoid tumours in routine histopathology.


Aug 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·T RossiP Toivanen
Apr 11, 1981·Lancet·F J TapiaA G Pearse
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Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·J McCutcheon, R A Walker
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·C BordiT D'Adda
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Jul 1, 1991·Journal of Clinical Pathology·U R SureshP S Hasleton
Oct 1, 1986·Pathology, Research and Practice·J M NeslandJ V Johannessen
Jun 1, 1985·The Journal of Pathology·C N LiddleC H Horne
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