Immunolocalization of prolyl 4-hydroxylase subunits, alpha-smooth muscle actin, and extracellular matrix components in human lens capsules with lens implants

Experimental Eye Research
Shizuya SaikaA Yamanaka

Abstract

Lens capsules become fibrotic after the extraction of a cataract. To understand this phenomenon, we evaluated the immunolocalization of prolyl 4-hydroxylase (an enzyme involved in procollagen hydroxylation), and extracellular matrix components and cytoskeletal components in a normal human lens capsule and in others with intraocular lenses. Lens capsules containing intraocular lenses were removed from a patient with proliferative vitreoretinopathy and three with proliferative diabetic retinopathy during vitreous surgery. Two circular sections of the anterior capsules with lens epithelial cells were obtained by anterior capsulotomy during cataract surgery. In addition, a lens capsular bag was obtained immediately after phacoemulsification. The lens capsules were processed for light microscopic immunohistochemical detection of the alpha and beta subunits of prolyl 4-hydroxylase, extracellular matrix components (including collagen types, laminin and cellular fibronectin) or cytoskeletal components (such as cytokeratin, vimentin and alpha-smooth muscle actin). Monolayer lens epithelial cells were seen on the inner surface of the normal anterior capsules. Each intraocular lens was found to be fixed in the capsular bag. Light microsco...Continue Reading

References

Mar 1, 1992·Journal of Cataract and Refractive Surgery·S SaikaH Iwane
Jan 1, 1991·Journal of Hepatology·T PihlajaniemiK I Kivirikko
Jan 1, 1990·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·R KanagawaT Nakao
May 1, 1989·The Journal of Clinical Investigation·T B ConnorM Lansing
Jan 1, 1985·Annals of the New York Academy of Sciences·K I Kivirikko, R Myllylä
Dec 15, 1986·American Journal of Ophthalmology·J P KappelhofG F Vrensen
Jan 1, 1985·Ophthalmology·J R Wolter
Sep 27, 1967·Biochemical and Biophysical Research Communications·T TakeuchiD J Prockop
Jul 1, 1984·Ophthalmology·P J McDonnellW R Green
Mar 1, 1980·The Journal of Experimental Medicine·K AlitaloA Vaheri
Nov 1, 1994·Journal of Cataract and Refractive Surgery·T IshibashiH Inomata
Feb 1, 1994·The Journal of Cell Biology·F Grinnell
Dec 1, 1993·Archives of Ophthalmology·T IshibashiH Inomata
Dec 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S SaikaS Uenoyama
Jul 1, 1993·Journal of Cataract and Refractive Surgery·U F LeglerS L Mowbray
Jul 1, 1993·Journal of Cataract and Refractive Surgery·O Nishi, K Nishi
Dec 1, 1995·Experimental Eye Research·S SaikaA Ooshima
Aug 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S SaikaY Ohnishi
Apr 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S SaikaM Kimura
Dec 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S SaikaA Yamanaka
Dec 1, 1996·The British Journal of Ophthalmology·C M Haus, A L Galand
Apr 1, 1997·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S SaikaM Kimura
Jan 1, 1996·Journal of Cataract and Refractive Surgery·S SaikaA Yamanaka
Aug 1, 1997·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S SaikaA Yamanaka

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Citations

Nov 26, 2002·The British Journal of Ophthalmology·S SaikaJ W McAvoy
Jan 30, 2002·The British Journal of Ophthalmology·Frank J LovicuJohn W McAvoy
Dec 19, 2009·Regenerative Medicine·Priya R Baraniak, Todd C McDevitt
Jun 19, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Małgorzata NitaWanda Romaniuk
Oct 13, 1998·Journal of Cataract and Refractive Surgery·S SaikaA Yamanaka
Oct 13, 1998·Journal of Cataract and Refractive Surgery·S SaikaA Yamanaka
May 28, 2013·Experimental Eye Research·Lazarina GyonevaVictor H Barocas
Jun 5, 2004·Journal of Cataract and Refractive Surgery·Sai-Ichi TanakaYoshitaka Ohnishi
Jun 5, 2004·Progress in Retinal and Eye Research·Shizuya Saika
Oct 3, 2006·Journal of Cataract and Refractive Surgery·Ai KitanoYoshitaka Ohnishi
Feb 14, 2006·Journal of Cataract and Refractive Surgery·Heinrich Bleckmann, Richard J Keuch
Jul 26, 2005·Journal of Cataract and Refractive Surgery·Iku IshidaYoshitaka Ohnishi
Apr 7, 2005·Journal of Cataract and Refractive Surgery·Ulrike SponerChristian Skorpik
Jan 27, 2004·The American Journal of Pathology·Shizuya SaikaAnita B Roberts
Nov 24, 1999·Journal of Cataract and Refractive Surgery·R J LinnolaT Pihlajaniemi
Jun 15, 2011·Journal of Proteome Research·Maurizio RonciNicolas H Voelcker
Apr 16, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Kevin A MarunoJohn W McAvoy
Mar 20, 2004·Journal of Cataract and Refractive Surgery·Kumi ShiraiYoshitaka Ohnishi
Jan 11, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shizuya SaikaYoshitaka Ohnishi
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Leonid M ZukinJ Mark Petrash
Jun 30, 2006·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Akio YamanakaHidetoshi Iwamoto
Feb 11, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yvonne de Jong-HesseGabriele E Lang
Dec 13, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shizuya Saika
Jul 20, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shizuya SaikaAnita B Roberts
Aug 6, 2002·Journal of Cataract and Refractive Surgery·Shizuya SaikaAkira Ooshima
Feb 18, 2004·Journal of Cataract and Refractive Surgery·Hiroyuki MatsushimaJohn I Clark
Oct 31, 1998·Journal of Cataract and Refractive Surgery·S SaikaA Yamanaka
Jul 15, 1999·Journal of Cataract and Refractive Surgery·D KurosakaN Ando
Jun 1, 2000·Journal of Cataract and Refractive Surgery·S SaikaA Ooshima
Aug 8, 2001·Journal of Cataract and Refractive Surgery·G van Setten
Aug 8, 2001·Journal of Cataract and Refractive Surgery·S SaikaA Ooshima
Feb 1, 2002·Journal of Cataract and Refractive Surgery·Shizuya SaikaWataru Kimura
Jan 29, 2003·Journal of Cataract and Refractive Surgery·Reijo J LinnolaTaina Pihlajaniemi

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