Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors

Ophthalmic Research
Junichi FukuharaSusumu Ishida

Abstract

We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans. Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression. Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels. The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.

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Citations

Jul 11, 2013·Journal of Ophthalmology·Wenting LuoDawei Sun
Aug 20, 2015·Critical Reviews in Clinical Laboratory Sciences·Roos PannecoeckMarijn M Speeckaert
Jul 26, 2016·International Journal of Endocrinology·Zhigang HuWeiyuan Ma
Feb 26, 2016·BMC Cancer·Stephen T WardDavid H Adams

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